Results 61 to 70 of about 50,612 (311)

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus

Laboratory Animal Research, 2023
Background Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure.
Min-Jung Park, Hyun Sik Na, Young-Shin Joo, Keun-Hyung Cho, Se-Young Kim, Jeong Won Choi, Jin-Ah Baek, Jong Young Choi, Young Kyoung You, Mi-La Cho   +9 more
doaj   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

In vivo and ex vivo methods of growing a liver bud through tissue connection

Scientific Reports, 2017
Cell-based therapy has been proposed as an alternative to orthotopic liver transplantation. The novel transplantation of an in vitro-generated liver bud might have therapeutic potential.
Yusuke Yanagi, Koichi Nakayama, Tomoaki Taguchi, Shin Enosawa, Tadashi Tamura, Koichiro Yoshimaru, Toshiharu Matsuura, Makoto Hayashida, Kenichi Kohashi, Yoshinao Oda, Takayoshi Yamaza, Eiji Kobayashi   +11 more
doaj   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

In vitro proliferation and differentiation of hepatic oval cells and their potential capacity for intrahepatic transplantation

Brazilian Journal of Medical and Biological Research, 2013
Hepatic oval cells (HOCs) are recognized as facultative liver progenitor cells that play a role in liver regeneration after acute liver injury. Here, we investigated the in vitro proliferation and differentiation characteristics of HOCs in order to ...
Z. Li, J. Chen, L. Li, J.H. Ran, J. Liu, T.X. Gao, B.Y. Guo, X.H. Li, Z.H. Liu, G.J. Liu, Y.C. Gao, X.L. Zhang   +11 more
doaj   +1 more source

Covered Self-Expanding Metal Stents Versus Multiple Plastic Stents in Treating Biliary Strictures Post-Orthotopic Liver Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

DEN Open
ABSTRACT Objectives Anastomotic biliary strictures are a common complication following orthotopic liver transplantation (post‐OLT), impacting morbidity and graft survival. This meta‐analysis evaluates the efficacy, safety, and cost‐effectiveness of covered self‐expanding metal stents (cSEMS) versus multiple plastic stents (MPS) for treating post‐OLT ...
Rocha Fernandes Y, Visconti TAC, Dall'Agnol MK, Ardengh AO, Veras MO, Valentim ESDS, Lera Dos Santos ME, Matuguma SE, Bernardo WM, de Moura EGH.   +9 more
europepmc   +2 more sources

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Early occurrence of acute myelomonocytic leukemia (M4/M5) after liver transplantation: a case report

Journal of Medical Case Reports, 2023
Introduction Acute myeloid leukemia is a rare event in post-liver-transplantation recipients. In the present report, we described a case of extramedullary acute myeloid leukemia, M4/M5 subtype, following orthotopic liver transplant. Case presentation The
Farhad Zamani, Hanie Karimi, Mohsenreza Mansoorian, Ali Basi, S. Ahmad Hosseini, Zahra Zahed, Nasim Seyedghasemipour, Roghayeh Sahraie   +7 more
doaj   +1 more source

Cadaveric small bowel and small bowel-liver transplantation in humans [PDF]

, 1992
Five patients had complete cadaveric small bowel transplants under FK506 immunosuppression, one as an isolated graft and the other 4 in continuity with a liver. Three were children and two were adults.
Abu-Elmagd, K, Casavilla, A, Demetris, AJ, Fung, JJ, Iwaki, Y, Jain, A, Murase, N, Nakamura, K, Reyes, J, Starzl, TE, Thiel, DV, Todo, S, Tzakis, AG, Yagihashi, A   +13 more
core   +1 more source