Results 131 to 140 of about 60,818 (269)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

B. burgdorferi tolerates a narrow range of osmolarity (250 to 650 mOsm).

, 2016
(A) A drawing of an I. scapularis tick showing the measurements used to determine scutal index: A = idiosoma length, B = scutal width [35]. (B) Development of the scutal index during feeding of nymph and adult ticks.
Kevin Lawrence (40102), Sébastien Bontemps-Gallo (2941824), Frank C. Gherardini (222597)   +2 more
core   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

Effect of Religious Fasting on Tear Osmolarity and Ocular Surface

, 2014
Objective: To evaluate the effects of religious fasting on tear secretion, tear osmolarity, corneal topography, and ocular aberrations. Methods: This prospective controlled study comprised 29 eyes of 29 healthy men. Before ophthalmologic examination, all
Bozkurt, Banu, Koktekir, Bengu Ekinci, Okudan, Suleyman, Gedik, Sansal, Gonul, Saban   +4 more
core   +1 more source

Cofactors in Anaphylaxis: Insights From the European Anaphylaxis Registry

Clinical &Experimental Allergy, EarlyView.
Forty‐nine per cent of reactions reported suspected cofactors (26% of children/adolescents, 59% of adults). Adjusted odds ratios for reaction severity increased with increasing number of suspected cofactors. Consistent effects for individual suspected cofactors were only observed for acute infections (children) and alcohol (adults with food‐induced ...
Margitta Worm, Sabine Dölle‐Bierke, Guillaume Pouessel, Franziska Ruëff, Karin Hartmann, Claudia Pföhler, Maria Beatrice Bilò, Nicola Wagner, Nikolaos G. Papadopoulos, Lars Lange, Andrea Bauer, Johannes Trück, Paul J. Turner, Veronika Höfer   +13 more
wiley   +1 more source

Influence of osmolarity of perfusate on contractility of mammalian myocardium

, 1963
The effect of changes in the osmolarity of the perfusing fluid on strength and time course of myocardial contraction was studied in cat papillary muscles and atrial strips. Osmolar concentration was varied by adding up to 750 mm sucrose or mannitol to a
Jan Koch-Weser
core   +1 more source

Sensitization profiles in patients with wheat‐dependent exercise‐induced anaphylaxis: practical aspects for allergy workup

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Wheat‐dependent exercise‐induced anaphylaxis (WDEIA) occurs after ingestion of wheat/gluten in the presence of various cofactors. Here, we characterized the sensitization spectrum to various wheat flours, as revealed by skin prick test (SPT) and specific IgE (sIgE) against wheat flour, gluten, and various wheat components.
Enna M. Schwarze, Carolin C. Albers, Randolf Brehler, Mathias Sulk   +3 more
wiley   +1 more source

Extracellular fluid viscosity influences the mechanics and migration of MDA‐MB‐231 cells in a macromolecule‐dependent manner

The FEBS Journal, EarlyView.
Macromolecule‐dependent increases in extracellular fluid viscosity alter cell phenotype. These distinct macromolecules create different extracellular environments that modulate cell morphology and mechanoprotein expression, migration and invasion capacity, and cellular mechanical properties.
Ian M. Smith, Nikka Givpoor, Chenchen Handler, Ariel Abraham, Shohini Banerjee, Giuliano Scarcelli, Kimberly M. Stroka   +6 more
wiley   +1 more source

Tear film osmolarity in dogs, cats and horses

, 2011
Die Osmolarität des Tränenfilms ist als vielversprechender Parameter in der ophthalmologischen Diagnostik angesehen. Hyperosmolarität ist ein grundlegendes Phänomen entzündlicher Prozesse, von besonderer Relevanz beim Trockenen Auge (Keratoconjunctivitis
Korth, Regina Maria Elfriede
core   +1 more source