Results 131 to 140 of about 5,737,881 (226)

Camels as a Climate‐Resilient Linchpin for Sustainable Development in Global Drylands

open access: yesSustainable Development, EarlyView.
ABSTRACT Camels represent a significant, yet underutilized, asset for advancing integrated sustainable development in the world's expanding drylands. Previous reviews have examined camels' physiology, milk composition, or pastoral systems in isolation; this review examines their potential as a climate‐resilient linchpin for food systems by synthesizing
Ayana Angassa   +2 more
wiley   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

open access: yesSmall, EarlyView.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim   +4 more
wiley   +1 more source

Ultra‐Tough Hybrid Supramolecular Gelatin Hydrogels

open access: yesSmall, EarlyView.
Tannic acid‐mediated coacervation compacts gelatin into a dense supramolecular network while generating an acidic microenvironment that activates pre‐embedded bis‐oxazoline crosslinkers. The resulting hybrid hydrogel combines covalent stabilization with reversible energy dissipation, producing high strength, extreme extensibility, substantial toughness,
Patrick Shakari   +6 more
wiley   +1 more source

Resource Availability Modulates Effects of Fluorine Free Firefighting Foams

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Fluorine‐free foam (F3) alternatives that lack per‐ and polyfluoroalkyl substances (PFAS) are rapidly being adopted for firefighting operations and will be entering ecosystems. Despite this, little is known about their impact on freshwater communities.
Jack D. Morehouse   +2 more
wiley   +1 more source

Urban oases relax desiccation risk for an arid‐adapted lizard

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Urbanization from expanding human development has radically altered the structure, ecology and microclimate of landscapes worldwide. These dramatic environmental alterations subject organisms to novel ecological conditions and may select for distinct ecophysiological ...
Tucker C. Heptinstall   +8 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

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