Results 71 to 80 of about 30,415 (229)

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

British Journal of Pharmacology, Volume 182, Issue 24, Page 6063-6080, December 2025.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce, Valeria Tomati, Valeria Capurro, Mariateresa Lena, Cristina Pastorino, Miro Astore, Serdar Kuyucak, Benoit Chevalier, Elvira Sondo, Federico Cresta, Alice Dighero, Vito Terlizzi, Cristina Fevola, Stefano Costa, Maria Cristina Lucanto, Valeria Daccò, Laura Claut, Francesca Ficili, Benedetta Fabrizzi, Renata Bocciardi, Federico Zara, Carlo Castellani, Luis J. V. Galietta, Shafagh A. Waters, Alexandre Hinzpeter, Nicoletta Pedemonte   +25 more
wiley   +1 more source

Use and effectiveness of dapagliflozin in routine clinical practice. An Italian multicenter retrospective study [PDF]

, 2018
In randomized controlled trials (RCTs), sodium-glucose co-transporter-2 (SGLT2) inhibitors have been shown to confer glycaemic and extra-glycaemic benefits.
Avogaro A, Baldi I, Bottigliengo D, Consoli A, DARWIN-T2D network., Fadini GP, Giaccari A, Sesti G, Zatti G   +8 more
core   +2 more sources

Patch Testing Under Biologics: Six Cases From a Tertiary Centre

Contact Dermatitis, Volume 94, Issue 3, Page 299-301, March 2026.
Alessandra Chiei‐Gallo, Francesca Barei, Angelo V. Marzano, Silvia M. Ferrucci   +3 more
wiley   +1 more source

Characterization of Breakthrough Hemolysis in Patients With Paroxysmal Nocturnal Hemoglobinuria: An International Multicenter Experience

American Journal of Hematology, Volume 100, Issue 11, Page 1963-1971, November 2025.
ABSTRACT Breakthrough hemolysis (BTH) is defined as a hemolytic exacerbation in a patient with paroxysmal nocturnal hemoglobinuria (PNH) treated with complement inhibitors (CIs). In the current era of several terminal and proximal inhibitors, there are no guidelines for defining BTH and its severity, and clinical management is not standardized.
Bruno Fattizzo, Giacinto Luca Pedone, Elisabetta Metafuni, Eloise Beggiato, Valentina Giai, Esther Natalie Oliva, Antony Ricchiuti, Marta Bortolotti, Simona Raso, Daniela Carlino, Mara Memoli, Sofia Vecchi, Jennifer Vidler, Sukanya Gogoi, Shreya Goel, Anna Corby, Roochi Trikha, Sneha Balakrishnan, Francesco Passamonti, Anna Paola Iori, Simona Sica, Shreyans Gandhi, Wilma Barcellini, Austin Kulasekararaj   +23 more
wiley   +1 more source

Le città dimenticate. Dalla città per la cura alla cura per la città

Festival dell'Architettura Magazine, 2017
Machines à soigner, gli ospedali psichiatrici costruiti in relazione a prescrizioni della medicina, secondo una rispondenza precisa tra funzione-forma e dismessi dopo circa cento anni, sono stati a lungo oggetto di una damnatio memoriae.
Angela D'Agostino
doaj  

Quality assessment of medical record as a tool for clinical risk management: a three year experience of a teaching hospital Policlinico Umberto I, Rome [PDF]

, 2017
Introduction: The medical record was defined by the Italian Ministry of Health in 1992 as "the information tool designed to record all relevant demographic and clinical information on a patient during a single hospitalization episode".
Bontempi, Claudio, Cacchio, Domenico, Catanzaro, Stefania, Chiarini, Massimiliano, Colamesta, Vittoria, DE GIUSTI, Maria, Ferro, Giuseppe, Guzzo, Anna Santa, Lombardi, ANNA MARIA, Marinelli, Enrico, Miani, Anna, Palazzo, Caterina, Salvati, Annunziata, Sposato, DOMENICA PATRIZIA, Tecca, Mario, Ursillo, Paolo   +15 more
core   +1 more source

mRNA Vaccines: Current Applications and Future Directions

MedComm, Volume 6, Issue 11, November 2025.
mRNA vaccines represent an innovative platform that leverages messenger RNA technology to direct cells to produce specific antigens, thereby eliciting an immune response. mRNA vaccines offer high programmability and significantly improved stability and immunogenicity through nucleotide modifications and delivery systems such as lipid nanoparticles ...
Jianmei Li, Yixin Liu, Jie Dai, Li Yang, Feng Xiong, Jing Xia, Jing Jin, Yangping Wu, Xingchen Peng   +8 more
wiley   +1 more source

Feasibility single-arm study of a medical device containing Desmodium adscendens and Lithothamnium calcareum combined with chemotherapy in head and neck cancer patients

Cancer Management and Research, 2018
Luca Imperatori,1 Damiano Giardini,2 Gino Latini,2 Giuseppe Migliori,2 Claudio Blasi,3 Feisal Bunkheila,3 Cesare Breschi,4 Rodolfo Mattioli,1 Silvia Pelliccioni,1 Carmen Laurino,5 Maria Vadalà,5 Beniamino Palmieri,5 Tommaso Iannitti6 1UOC ...
Imperatori L, Giardini D, Latini G, Migliori G, Blasi C, Bunkheila F, Breschi C, Mattioli R, Pelliccioni S, Laurino C, Vadala M, Palmieri B, Iannitti T   +12 more
doaj  

Future memorie. L’ex ospedale psichiatrico di Palermo

Festival dell'Architettura Magazine, 2017
La memoria dell’ex manicomio di Palermo ha un futuro. Il riuso del complesso può svelare alla comunità urbana vicende quotidiane di chi fu chiamato “pazzo”, monumenti, paradisi ipogei, altre tracce storiche e una nuova permeabilità dei percorsi cittadini.
Luciana Macaluso
doaj   +1 more source

L'evoluzione dell'istituzione manicomiale giudiziaria in Italia tra paradigmi psichiatrici e giuspenalistici. Luci ed ombre all'esito dell'importante riforma del 2012 [PDF]

, 2018
Sin dall’epoca classica c’è stata l’esigenza di riservare a coloro che commettevano reati a causa di patologie e problemi mentali un trattamento differente - perché non responsabili dei loro atti - rispetto ai criminali “normali”. Parimenti era avvertita
D'Auria, Stefano
core   +1 more source