Results 241 to 250 of about 39,993 (353)

Multifunctional ions/drugs co-delivering nanocomposite hydrogel orchestrates neuro-osteogenic microenvironment for boosting osteoporotic osseointegration. [PDF]

open access: yesJ Nanobiotechnology
Jin S   +14 more
europepmc   +1 more source

Controversies Surrounding Critical‐Size Defects: Influence of Age and Biological Characteristics

open access: yesJournal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 6, June 2026.
ABSTRACT Critical‐size defects (CSDs) in craniofacial reconstruction refer to osseous gaps that fail to heal spontaneously, increasing the risk of neurological impairment and craniofacial dysmorphology. Despite decades of investigation, controversy still exists surrounding the definition of CSDs, with criteria varying across species, experimental ...
Andrew Nordlund   +7 more
wiley   +1 more source

Dual effects of bisphosphonates on bone metabolism and implant osseointegration: mechanisms, risks and clinical strategies

open access: hybrid
Hongqi Liu   +8 more
openalex   +1 more source

In Vitro Evaluation of Novel Calcium Silicate‐Based and Resin‐Modified Calcium Silicate Materials: Cytocompatibility and Mineralization Potential on Human Dental Pulp Stem Cells for Pulp Repair

open access: yesMicroscopy Research and Technique, Volume 89, Issue 6, Page 932-947, June 2026.
This study demonstrates that Biodentine XP exhibits superior cytocompatibility, promotes odontogenic differentiation, and enhances mineralization in human dental pulp stem cells, supporting its use in regenerative endodontics. Resin‐modified materials showed lower bioactivity, highlighting the importance of material composition in pulp therapy outcomes.
Francisco Javier Rodríguez‐Lozano   +5 more
wiley   +1 more source

From Concept to Clinic: Pre‐Clinical Testing and Regulatory Considerations in Spine Implant Development

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Spine implant development follows a regulated, iterative pathway from clinical need and design through material selection, prototyping, preclinical validation, and regulatory approval to post‐market surveillance. Biomechanical evaluation and risk‐based frameworks integrate across all stages, ensuring safe, effective translation from concept to clinical
Amit Benady   +5 more
wiley   +1 more source

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