Results 21 to 30 of about 73,277 (253)

Macrophages in heterotopic ossification: from mechanisms to therapy

npj Regenerative Medicine, 2021
Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It is caused by an injury that stimulates abnormal tissue healing and regeneration, and inflammation is involved in this process.
Yifei Huang, Xinyi Wang, Daixuan Zhou, Wenwen Zhou, Fengyi Dai, Hui Lin   +5 more
semanticscholar   +1 more source

Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice

Science Signaling, 2021
Inhibition of endogenous activin A reduces heterotopic ossification and ectopic bone accumulation in mice. Endogenous activin A in ectopic bone formation Heterotopic ossification (HO) is the formation of ectopic bone in soft tissues at sites of injury ...
Christina Mundy, L. Yao, Sayantani Sinha, Juliet Chung, Danielle Rux, S. Catheline, E. Koyama, L. Qin, M. Pacifici   +8 more
semanticscholar   +1 more source

Engineered osteoclasts as living treatment materials for heterotopic ossification therapy

Nature Communications, 2021
Osteoclasts (OCs), the only cells capable of remodeling bone, can demineralize calcium minerals biologically. Naive OCs have limitations for the removal of ectopic calcification, such as in heterotopic ossification (HO), due to their restricted activity,
Wenjing Jin, Xianfeng Lin, H. Pan, Chenchen Zhao, P. Qiu, Ruibo Zhao, Zihe Hu, Yanyan Zhou, Haiyan Wu, Xiao Chen, H. Ouyang, Zhijian Xie, R. Tang   +12 more
semanticscholar   +1 more source

EARLY SURGERY IN RARE KNEE HETEROTOPIC OSSIFICATION LEADS TO SUCCESSFUL FUNCTIONAL OUTCOME: A CASE REPORT. [PDF]

J Rehabil Med Clin Commun
Background: Heterotopic ossification is a common complication after joint replacement surgery, such as hip or knee arthroplasty. In the intensive care unit, it is most commonly associated with traumatic brain injury or spinal cord injury.
Pierreux S, Hatem SM, Roggeman S, Schiltz M.   +3 more
europepmc   +2 more sources

Retinoid Agonists in the Targeting of Heterotopic Ossification

Cells, 2021
Retinoids are metabolic derivatives of vitamin A and regulate the function of many tissues and organs both prenatally and postnatally. Active retinoids, such as all trans-retinoic acid, are produced in the cytoplasm and then interact with nuclear ...
R. Pignolo, M. Pacifici
semanticscholar   +1 more source

Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification

Bone Research, 2021
Ankylosing spondylitis (AS) is chronic inflammatory arthritis with a progressive fusion of axial joints. Anti-inflammatory treatments such as anti-TNF-α antibody therapy suppress inflammation but do not effectively halt the progression of spine fusion in
Tao Yu, Jianguo Zhang, Wei Zhu, Xiao Wang, Yun Bai, B. Feng, Q. Zhuang, C. Han, Shengru Wang, Qi Hu, Senbo An, M. Wan, S. Dong, Jianzhong Xu, X. Weng, Xu Cao   +15 more
semanticscholar   +1 more source

Osteomyelitis in heterotopic ossification in a patient with congenital gigantism of the leg [PDF]

Journal of Bone and Joint Infection, 2021
This paper presents the first report of osteomyelitis in heterotopic ossification in a patient with macrodystrophia lipomatosa. Careful review of magnetic resonance imaging allowed correct diagnosis and design of a limited surgical excision ...
M. Galea Wismayer, M. Galea Wismayer, K. Sant, R. Giordmaina, M. McNally, M. McNally   +5 more
doaj   +1 more source

Rapid Progression of Heterotopic Ossification in Severe Variant of Fibrodysplasia Ossificans Progressiva with p.Arg258Gly in ACVR1: A Case Report and Review of Clinical Phenotypes

Case Reports in Genetics, 2022
Fibrodysplasia ossificans progressiva (FOP) is a rare skeletal disorder characterized by congenital malformation of the great toes and progressive heterotopic ossification.
Kosei Hasegawa, Hiroyuki Tanaka, Natsuko Futagawa, Hiroyuki Miyahara, Hirokazu Tsukahara   +4 more
doaj   +1 more source

Bilateral severe heterotopic ossification following primary total knee arthroplasty: a case report in Pakistan

Arthroplasty, 2021
The incidence of unilateral minor heterotopic ossification after primary total knee arthroplasty is still unknown, but bilateral severe heterotopic ossification is rare and has not been reported before.
Faizan Iqbal, Nouman Memon, Syed Shahid Noor, Nasir Ahmed, Muhammad Farhan Sozera, Arsalan Abro   +5 more
doaj   +1 more source

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

Nature Communications, 2020
Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) differentiate into osteochondrogenic cells instead of myocytes or tenocytes ...
M. Sorkin, A. Huber, Charles D. Hwang, W. F. Carson, R. Menon, Jonathan Li, Kaetlin Vasquez, Chase A. Pagani, Nicole Patel, Shuli Li, Noelle D. Visser, Y. Niknafs, Shawn Loder, Melissa M. Scola, Dylan Nycz, Katherine A. Gallagher, L. McCauley, Jiajia Xu, A. James, Shailesh Agarwal, S. Kunkel, Y. Mishina, B. Levi   +22 more
semanticscholar   +1 more source