Results 291 to 300 of about 708,008 (375)

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Radiographic Severity and Clinical Implications of Knee Osteoarthritis in Adults Under 55: Incidence and Insight Into Potential Candidates for Geniculate Artery Embolisation. [PDF]

Cureus
Solomon DJ, McLoughlin P.
europepmc   +1 more source

Osteoarthritis: a disease of the joint as an organ.

Arthritis & Rheumatism, 2012
R. Loeser, S. Goldring, C. Scanzello, M. Goldring   +3 more
semanticscholar   +1 more source

Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase‐2 Inhibitor

ChemMedChem, EarlyView.
Two macromolecular ester prodrugs of a COX‐2 inhibitor are designed and synthesized. They are based on two different oligo(ethylene glycol) spacers linking the COX‐2 inhibitor to hyaluronic acid. The spacers are designed to differ in the sensitivity to the hydrolytic conditions.
Mario Saletti, Marco Paolino, Jacopo Venditti, Germano Giuliani, Antonietta Rossi, Danilo D’Avino, Sara Perna, Ina Varfaj, Roccaldo Sardella, Antonio Macchiarulo, Samuele Maramai, Stefania Lamponi, Andrea Cappelli, Maurizio Anzini   +13 more
wiley   +1 more source

Analysis of key genes and pathways of knee osteoarthritis based on GEO data mining. [PDF]

Medicine (Baltimore)
Gao Y.
europepmc   +1 more source

A lactate metabolism-related gene signature to diagnose osteoarthritis based on machine learning combined with experimental validation

Jianhua Yang, Wenjun Li, Xuemei Lin, Liang Wei   +3 more
openalex   +1 more source

Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis

Clinical Orthopaedics and Related Research, 2016
Mark D Kohn, A. Sassoon, Navin D. Fernando   +2 more
semanticscholar   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Exploring the therapeutic potential of epsom salt bath on pain and intensity of knee osteoarthritis: Randomized controlled trial. [PDF]

J Educ Health Promot
Kumar V, Shyoran R, Pareek B, Pathania R, Ranaut R, Ravi RK.   +5 more
europepmc   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source