Results 301 to 310 of about 708,008 (375)

Cannabis Use and Analgesic Prescribing in UK Primary Care: A Retrospective Cohort Study of Patients with Osteoarthritis. [PDF]

Medicines (Basel)
Erridge S, Chandan JS, Gokhale KM, Billinghurst C, Sodergren MH.   +4 more
europepmc   +1 more source

Comorbidity trajectories before and after the diagnosis of heart failure: A UK Biobank cohort study

European Journal of Heart Failure, EarlyView.
Time of diagnosis of comorbidities in relation to heart failure. COPD, chronic obstructive pulmonary disease; MI, myocardial infarction. Abstract Aims Heart failure (HF) is frequently associated with multiple comorbidities. We aimed to define their trajectory of accrual to identify opportunities for disease prevention. Methods and results We identified
Hugo MacGowan, Oliver I. Brown, Michael Drozd, Andrew M.N. Walker, Marilena Giannoudi, Sam Straw, Maria F. Paton, John Gierula, Melanie McGinlay, Kathryn J. Griffin, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon   +12 more
wiley   +1 more source

Why pharmacy practice needs quality indicators. [PDF]

Can Pharm J (Ott)
Tadrous M, Liu S, Tsuyuki RT.
europepmc   +1 more source

Multiple Strategies for Recombinant Expression of Human Chymotrypsinogen C in Pichia Pastoris

Food Bioengineering, EarlyView.
Human chymotrypsin C (CTRC), a food‐processing protease, was expressed in Pichia pastoris via three strategies: replacing the AOX1 promoter with HpHMD, rDNA locus‐based gene integration, and engineering the pro2M mutant to evade host protease degradation. The pro2M showed 3.3‐fold higher specific activity (54.84 U/mg) and improved secretion relative to
Yi Liu, Yu Xie, Xingyu Shen, Shihui Wang, Yi Xiong, Guimin Zhang   +5 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

From detection to grading: A hybrid KOA-YOLOv5-RF model for knee osteoarthritis diagnosis. [PDF]

MethodsX
Perumalsamy M, Govindarajan P, Bran R, Kp AK, Jyothi NV, Batumalay M.   +5 more
europepmc   +1 more source

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, EarlyView.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Erratum to 'Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study' [Osteoarthritis and Cartilage Open 5 (2023) 100414]. [PDF]

Osteoarthr Cartil Open
Thompson W, Swain S, Zhao SS, Kamps A, Coupland C, Kuo C, Bierma-Zeinstra S, Runhaar J, Doherty M, Zhang W.   +9 more
europepmc   +1 more source

Intermediate-term hip survivorship and patient-reported outcomes of periacetabular osteotomy: The Washington University Experience [PDF]

, 2018
Clohisy, John C, Duncan, Stephen, Goss, Charles W, Schoenecker, Perry, Thomason, Kayla, Wells, Joel   +5 more
core   +1 more source

Impacts of Diets and Food Plans in Health and Diseases—A Narrative Review

Food Safety and Health, EarlyView.
This review emphasizes different diet types, providing insights into their nutritional content and health effects. Vegetarian and vegan diets, ketogenic diets, Mediterranean diets, Western diets, pescatarian diets, flexitarian diets, and territorial diversified diets are discussed, highlighting their influences on health, and diseases.
Md. Mahbubar Rahman, Manisha Pandit, Bhawana Thukral, Morshed M. Khandoker   +3 more
wiley   +1 more source