Results 41 to 50 of about 6,415 (182)

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Design of dual-effect molecules based on lysosome-targeting strategy: a mechanistic study on synergistic inhibition of ewing sarcoma and coronaviruses

Frontiers in Chemistry
IntroductionAddressing clinical challenges such as the toxicity of conventional chemotherapy and viral drug resistance, this study proposes and validates an innovative “host organelle-targeting” strategy.
Shimeng Zhou, Lu Xu, Wenlong Ge
doaj   +1 more source

Identification of Sarcopenic Obesity by Fat‐to‐Muscle Ratio in Older Adults: A Cohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background The diagnosis of sarcopenic obesity has been established in Europe and Japan, but screening tools remain inconsistent and lack standardization. The fat‐to‐muscle ratio (FMR) is a potential screening measure for sarcopenic obesity; however, its diagnostic accuracy compared with other tools has not been evaluated.
Daisuke Kakita, Kenji Harada, Satoshi Kurita, Masanori Morikawa, Chiharu Nishijima, Kazuya Fujii, Hiroyuki Shimada, Hidenori Arai   +7 more
wiley   +1 more source

Pulsed Electromagnetic Field Therapy for Mild‐to‐Moderate Knee Osteoarthritis: A Double‐Blind, Randomized, Placebo‐Controlled Clinical Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Current treatments for knee osteoarthritis (OA) offer limited functional and structural improvements. Compared to age‐ and gender‐matched controls, patients with knee OA show a higher prevalence of muscle weakness, which negatively affects their ability to exercise—a key factor in enhancing physical mobility and delaying disease ...
Kenney Ki Lee Lau, Abbey Ssu Chi Chen, Christine Hoi Yan Fu, Jonathan Patrick Ng, Michael Tim Yun Ong, Patrick Shu Hang Yung, Pauline Po Yee Lui   +6 more
wiley   +1 more source

Efficiency assessment of phytocomplex phonophoresis in rehabilitation of patients with knee joint osteoarthrosis [PDF]

Саратовский научно-медицинский журнал, 2013
Objective: the comparative research of phytocomplex phonophoresis rehabilitation efficiency of patients with knee joint osteoarthrosis. Material and Methods, the study included 100 patients with knee joint osteoarthrosis; the effectiveness evaluation was
Kotenko К.V., Babaskin D.V.
doaj  

Non‐resectable extratesticular sustentacular cell tumour treated with palliative‐intent radiation and carboplatin chemotherapy in a dog

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract There is limited published information regarding the diagnosis and treatment of sustentacular cell neoplasia in dogs, and no data evaluating the use of radiation and chemotherapy for those tumours that are non‐resectable. This case report describes a 5‐year‐old, male, neutered German shepherd dog presented with a large, rapidly growing ...
Kathryn J. Jensen, Dah‐Renn Fu, Christopher Premanandan, Rhonda Burge   +3 more
wiley   +1 more source

Interrater variability in manual palpation of the medial femorotibial joint of Warmbloods and American Quarter Horses based on experience level

Equine Veterinary Education, Volume 38, Issue 2, Page 77-84, February 2026.
Summary Background Manual palpation of the equine medial femorotibial joint (MFT) is commonly performed during lameness evaluation. Previous studies have shown poor inter‐observer agreement between experienced clinicians and between stifle effusion palpation and ultrasonography.
K. L. Ellis, G. E. Aguirre, M. Perlini, V. J. Moorman, S. Giancola, L. Fidler, V. Knopp, M. R. Goldberg, E. Pearson, A. Dockery   +9 more
wiley   +1 more source

Targeting glial scar formation for spinal cord injury: mechanisms, strategies, and research progress review

Frontiers in Neuroscience
Spinal cord injury is often followed by the formation of a glial scar which acts as a major barrier for axonal regrowth and recovery after spinal injuries.
Chaochao Zhang, Chaochao Zhang, Jiaxiao Shi, Jiaxiao Shi   +3 more
doaj   +1 more source

Osteoarthrosis of Temporomandibular Joint Related to the Defects of Posterior Dentition: A Retrospective Study

Prague Medical Report, 2016
Osteoarthrosis (OA) of temporomandibular joint (TMJ) is a progressive degenerative disease, gradually affecting cartilage, synovial membrane and bone structures. OA of TMJ clinically manifests with joint noises, pain and restricted mouth opening. In late
Jitka Levorová, Vladimír Machoň, Anasuya Guha, René Foltán   +3 more
doaj   +1 more source

Self‐Management Therapies for Temporomandibular Disorders—Evidence From Systematic Reviews

Journal of Oral Rehabilitation, Volume 53, Issue 1, Page 265-281, January 2026.
This umbrella review synthesized existing evidence on self‐management therapy for temporomandibular disorder. ABSTRACT Objectives Chronic pain in the orofacial region affects 10%–15% of the general population. It is most often related to temporomandibular disorders (TMD): pain in the masticatory muscles and the temporomandibular joints.
Tessa Bijelic, Ambrosina Michelotti, Rosaria Bucci, Daniela Del Sorbo, EwaCarin Ekberg, Birgitta Häggman‐Henrikson   +5 more
wiley   +1 more source