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Increased bone formation in osteocalcin-deficient mice [PDF]

Nature, 1996
VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new hone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A fen molecular determinants of bone remodelling that
P. Ducy, C. Desbois, B. Boyce, G. Pinero, B. Story, C. Dunstan, Erica Smith, J. Bonadio, S. Goldstein, C. Gundberg, A. Bradley, G. Karsenty   +11 more
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Polygonatum cyrtonema Hua Polysaccharide Alleviates Fatigue by Modulating Osteocalcin-Mediated Crosstalk between Bones and Muscles.

Journal of Agricultural and Food Chemistry, 2023
Osteocalcin was reported to regulate muscle energy metabolism, thus fighting fatigue during exercise. The current work aimed to investigate the anti-fatigue effect and the underlying mechanism of a homogeneous polysaccharide (PCPY-1) from Polgonatum ...

semanticscholar   +1 more source

Polygonatum cyrtonema Hua polysaccharide exhibits anti-fatigue activity via regulating osteocalcin signaling.

International Journal of Biological Macromolecules, 2021
In the present study, we explored the anti-fatigue activity and its potential mechanism of a purified Polygonatum cyrtonema polysaccharide (PCP) on mice using weight-loaded swimming test.
Wen-Di Shen, Xue-ying Li, Y. Deng, X. Zha, Li-Hua Pan, Qiang‐Ming Li, Jian-ping Luo   +6 more
semanticscholar   +1 more source

What is the function of osteocalcin?

Journal of Oral Biosciences, 2020
: Osteocalcin is the most abundant non-collagenous protein in bone and is specifically expressed in osteoblasts. Previous studies using osteocalcin-deficient (Ocn-/-) mice demonstrated that osteocalcin inhibits bone formation, and serum uncarboxylated ...
T. Komori
semanticscholar   +1 more source

Contribution of osteocalcin-mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells.

Colloids and Surfaces B: Biointerfaces, 2019
A natural peptide motif in the first helix of osteocalcin (OCN) is used to promote nucleation and crystallization of hydroxyapatite (HA) in hard tissue.
S. Hosseini, H. Naderi-manesh, H. Vali, M. Baghaban Eslaminejad, Forough Azam Sayahpour, S. Sheibani, S. Faghihi   +6 more
semanticscholar   +1 more source

Osteocalcin improves insulin resistance and inflammation in obese mice: Participation of white adipose tissue and bone.

Bone, 2017
AIMS/HYPOTHESIS The discovery of osteocalcin, a protein synthetized by osteoblasts, as a hormone that has positive effects on insulin resistance, contributed to support the concept of bone as an endocrine organ.
J. A. C. Guedes, J. V. Esteves, M. R. Morais, T. Zorn, D. Furuya   +4 more
semanticscholar   +1 more source

Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis.

Journal of Trace Elements in Medicine and Biology, 2018
The relationship between daily boron intake and osteocalcin-mediated osteoporosis was studied in boron-exposed postmenopausal women. It is known that boron and osteocalcin are important in bone metabolism, however the effect of boron in bone metabolism ...
Olcay Boyacıoğlu, Seda Orenay-Boyacioglu, H. Yıldırım, M. Korkmaz   +3 more
semanticscholar   +1 more source

Osteocalcin and its endocrine functions.

Biochemical Pharmacology, 2017
Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, M. Hirata   +2 more
semanticscholar   +1 more source

Endocrine roles of vitamin K-dependent- osteocalcin in the relation between bone metabolism and metabolic disorders

Reviews in Endocrine & Metabolic Disorders, 2019
E. Al-Suhaimi, M. Al-Jafary
semanticscholar   +1 more source

Osteocalcin and Non-Alcoholic Fatty Liver Disease: Lessons From Two Population-Based Cohorts and Animal Models

Journal of Bone and Mineral Research, 2021
Hongmei Yan, Xin Gao, Hua Bian
exaly