Results 61 to 70 of about 32,840 (255)

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background The Wnt/β‐catenin pathway and its bone‐specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events, particularly
Bingna Zhou, Jing Hu, Yuanyuan Yu, Lei Sun, Yanye Wang, Qian Zhang, Yan Jiang, Ou Wang, Xiaoping Xing, Weibo Xia, Luyao Wang, Ge Zhang, Mei Li   +12 more
wiley   +1 more source

Adults with osteogenesis imperfecta: Clinical characteristics of 151 patients with a focus on bisphosphonate use and bone density measurements

Bone Reports, 2018
An expert center for adults with Osteogenesis Imperfecta (OI) has been founded at the Isala Hospital in Zwolle, the Netherlands to achieve optimal care for adults with OI.
Luuk J.J. Scheres, Fleur S. van Dijk, Arjan J. Harsevoort, Atty T.H. van Dijk, Anne Marieke Dommisse, Guus J.M. Janus, Anton A.M. Franken   +6 more
doaj  

Osteogenesis Imperfecta: A study of the patient journey in 13 European countries

Orphanet Journal of Rare Diseases
Introduction Osteogenesis imperfecta (OI) is a heritable skeletal disorder and comprises various subtypes that differ in clinical presentation, with Type I considered the least severe and Types III/IV the most severe forms.
Ingunn Westerheim, Valerie Cormier-Daire, Scott Gilbert, Sean O’Malley, Richard Keen   +4 more
doaj   +1 more source

Osteogénesis imperfecta

Anales de la Facultad de Medicina, 2014
Este trabajo tiene por objeto el estudio de una afección ósea rara tanto en nuestro medio como en otros países, y fue realizado en un lapso de tres años, mediante observación sistemática de 4 pacientes internados en el Hospital del Niño, a los que se ha agregado otros 4 enfermos que han sido tomados de la Estadística de este nosocomio, entre los años ...
openaire   +4 more sources

Understanding hearing health‐care access in Australia: Users' perspectives

Australasian Journal on Ageing, Volume 44, Issue 2, June 2025.
Abstract Objective The aim of this qualitative study was to evaluate the barriers and enablers to current hearing health‐care services in Australia for middle‐aged and older adults who use cochlear implants (CI) and/or hearing aids. Methods Adults aged 40 years and older from the Hearing impairment Adults: a Longitudinal Outcomes Study (HALOS), with ...
Shermin Lim, Jessica Turner, Diana Tang, Kerry Sherman, Kompal Sinha, Sharad Chawla, Simon Carney, Giriraj Singh Shekhawat, Bamini Gopinath   +8 more
wiley   +1 more source

3D Micron-scale Imaging of the Cortical Bone Canal Network in Human Osteogenesis Imperfecta (OI) [PDF]

, 2013
Osteogenesis imperfecta (OI) is a genetic disorder leading to increased bone fragility. Recent work has shown that the hierarchical structure of bone plays an important role in determining its mechanical properties and resistance to fracture. The current
Albert, Carolyne, Busse, Bjoern, Harris, Gerald F., Jameson, John R., Smith, Peter A.   +4 more
core   +1 more source

Urinary pyridinoline cross-links as biomarkers of osteogenesis imperfecta. [PDF]

, 2015
Osteogenesis imperfecta (OI) is a group of genetic heterogeneous connective tissue disorders characterized by increased bone fragility and susceptibility to fractures.
Baumgartner, M.R., Bonafé, L., Campos-Xavier, A.B., Giunta, C., Kraenzlin, M., Lindert, U., Rohrbach, M.   +6 more
core   +1 more source

A Deep Intronic Splice Variant in COL1A1 Causing Osteogenesis Imperfecta Type II

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Osteogenesis imperfecta (OI) is a rare disease, hallmarked by bone fragility, multiple fractures, and deformities, and is commonly caused by pathogenic variants in the genes encoding type I collagen. Type II OI is the most severe form and is lethal in the perinatal period. Here, we report recurrence of perinatal lethal OI in two fetuses due to
Mackenna E. Schouw, Claudia A. L. Ruivenkamp, Tamara T. Koopmann, Gijs W. E. Santen, Peter G. J. Nikkels, Karin van der Tuin   +5 more
wiley   +1 more source

Osteogenesis imperfecta and pregnancy: a case report

Journal of Medical Case Reports, 2019
Background Osteogenesis imperfecta is a rare connective tissue disorder of varying phenotypic presentations. In pregnancies complicated by osteogenesis imperfecta, there is an increased risk to both the mother and fetus.
Felix Chamunyonga, Kudzaishe Lloyd Masendeke, Bismark Mateveke   +2 more
doaj   +1 more source

Dental management of a child with a rare bone disorder: a case report with a six-year follow up

RGO: Revista Gaúcha de Odontologia, 2020
Osteogenesis imperfecta is a rare genetic disorder involving abnormal type I collagen composition that compromises bone and collagen-rich tissues. Individuals with Osteogenesis imperfecta exhibit oral and systemic abnormalities, including dentinogenesis ...
Suélen Alves TEIXEIRA, Mariana Oliveira GUIMARÃES, Natália Mendes De Matos CARDOSO, Raiane Machado MAIA, Natália Cristina Ruy CARNEIRO, Ana Cristina BORGES-OLIVEIRA   +5 more
doaj   +1 more source