Results 101 to 110 of about 43,529 (272)

Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients

BMC Musculoskeletal Disorders, 2017
BackgroundTumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. Nonspecific symptoms make the diagnosis elusive. In addition, locating the responsible tumor(s) is challenging.
Q. Zuo, Hong Wang, Wei Li, X.-H. Niu, Yan-hong Huang, Jia Chen, Yuchen You, B. Liu, Ai-min Cui, Wei-dong Deng   +9 more
semanticscholar   +1 more source

MECP2 Insufficiency Attenuates RUNX2‐Dependent Osteoblast Differentiation via miR‐126‐3p/DKK1‐Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
MECP2 insufficiency leads to upregulation of miR‐126‐3p, which in turn enhances the endogenous Wnt antagonist DKK1. DKK1 inhibits the canonical Wnt signaling pathway, thereby impairing RUNX2‐dependent osteoblast differentiation. ABSTRACT Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by loss‐of‐function mutations in the gene encoding ...
Shuangshan Dong, Lu Wang, Hiroki Kato, Saki Hirofuji, Zhiyan Zhou, Yosuke Ito, Yuta Hirofuji, Hiroshi Sato, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda   +12 more
wiley   +1 more source

Osteomalacia Induced by Renal Tubular Acidosis Type 1

Indonesian Journal of Rheumatology, 2017
Renal Tubular Acidosis, a group of disorders characterized by defective renal acid-base regulation, can impair mineralization of bone matrix in adults known as osteomalacia. RTA is classified into 3 major forms, such as proximal RTA or type 2; distal RTA
Steven Sutanto Sihombing, Anna Ariane, RM Suryo Anggoro Kusumo Wibowo, Bambang Setyohadi   +3 more
doaj   +1 more source

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing [PDF]

, 2015
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia ...
Carriero, A, Chang, Y M, Farquharson, C, Houston, D A, Javaheri, B, Kazeruni, B N, Millan, J L, Oldknow, K J, Pitsillides, A A, Salmon, P, Shefelbine, S, Staines, K A   +11 more
core   +4 more sources

Successful treatment of tumor-induced osteomalacia causing by phosphaturic mesenchymal tumor of the foot

Medicine, 2019
Tumor-induced osteomalacia causing by phosphaturic mesenchymal tumor of the foot is exceedingly rare, thus may bring great challenges to the timely and proper diagnosis and treatment of clinicians.
Shuzhong Liu, Xiaoping Zhou, A. Song, Z. Huo, Yipeng Wang, W. Xia, Yong Liu   +6 more
semanticscholar   +1 more source

Incidence of adverse events in iron‐deficient pregnant women and surgical patients undergoing intravenous iron treatment with ferric isomaltose or ferric carboxymaltose: A systematic review

Transfusion, EarlyView.
Dominik Heger, Johannes Volkmann, Stephanie Weibel, Johanna Stoevesandt, Veronika Walzer, Peter Kranke, Patrick Meybohm, Stephanie Stangl   +7 more
wiley   +1 more source

Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders

Clinical Genetics, Volume 109, Issue 2, Page 286-293, February 2026.
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs, Neelam Giri, Marena R. Niewisch, Sharon A. Savage   +3 more
wiley   +1 more source

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay, Sajin Marcus Cyr, Yorihiro Iwasaki, Elizabeth Hill, Eugene P. Rhee, Nevil J. Singh, Petra Simic, Murat Bastepe   +7 more
wiley   +1 more source

Combined pathology of bone tissue: osteoporosis and osteomalacia in patient with Parkinson’s disease (Clinical case report)

Bolʹ, Sustavy, Pozvonočnik, 2017
The article describes a case of combined osteoporosis and osteomalacia in a patient with Parkinson’s disease and vertebral pain syndrome. Osteomalacia caused by deficiency and metabolic disorders of vitamin D leads to osteoid mineralization impairment ...
V.V. Povoroznyuk, A.S. Musiienko, T.V. Parakhina, M.A. Bystrytska   +3 more
doaj   +1 more source

Phosphaturic mesenchymal tumor of the nasal cavity: Clinicopathologic correlation is essential for diagnosis

Human Pathology: Case Reports, 2019
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm in which the tumor cells produce fibroblast growth factor 23 (FGF23), leading to oncogenic osteomalacia and thus a distinct clinical presentation.
Aidan Kerr, Ryan Rimmer, Marc R. Rosen, James J. Evans, Madalina Tuluc, Stacey K. Mardekian   +5 more
doaj   +1 more source