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Osteomalacia

Revista de la Facultad de Medicina, 1958
El hueso está compuesto de una matriz ósea sobre la cual se deposita calcio y fósforo. La matriz ósea, a su turno está formada por una proteína, (colágeno) y por carbohidratos.
Ricardo Cediel
doaj   +3 more sources

Burosumab in Unidentifiable Tumor-Induced Osteomalacia. [PDF]

Clin Case Rep
ABSTRACT Tumor‐induced osteomalacia (TIO) can be challenging due to underlying tumors being either unresectable or unidentifiable. Burosumab, an anti‐FGF23 monoclonal antibody, has been proven to be effective in treating TIO but is currently not subsidized for this indication in Australia.
Der YS, Chaubey S, Mclean A, Trinh Y, Pember S, Sinha A.   +5 more
europepmc   +2 more sources

Osteomalacia in Adults: A Practical Insight for Clinicians

Journal of Clinical Medicine, 2023
The term osteomalacia (OM) refers to a series of processes characterized by altered mineralization of the skeleton, which can be caused by various disorders of mineral metabolism. OM can be genetically determined or occur due to acquired disorders, among
L. Arboleya, Ignacio Braña, E. Pardo, Marta Loredo, R. Queiró   +4 more
semanticscholar   +1 more source

Global guidance for the recognition, diagnosis, and management of tumor‐induced osteomalacia

Journal of Internal Medicine, 2022
Tumor‐induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23). Patients present with progressive bone pain, muscle weakness, and fragility fractures.
S. M. Jan de Beur, S. Minisola, W. Xia, B. Abrahamsen, J. Body, M. Brandi, R. Clifton-Bligh, M. Collins, P. Florenzano, P. Houillier, Y. Imanishi, E. Imel, Aliya A. Khan, M. Zillikens, Seiji Fukumoto   +14 more
semanticscholar   +1 more source

TUMOR-INDUCED OSTEOMALACIA: A COMPREHENSIVE REVIEW.

Endocrine reviews, 2022
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to overproduction of fibroblast growth factor 23 (FGF23), with profound effects on the morbidity of the patients affected.
S. Minisola, S. Fukumoto, Weibo Xia, A. Corsi, L. Colangelo, A. Scillitani, J. Pepe, C. Cipriani, R. Thakker   +8 more
semanticscholar   +1 more source

Tumor induced osteomalacia: a systematic review and individual patient's data analysis.

Journal of Clinical Endocrinology and Metabolism, 2022
CONTEXT Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome, usually caused by small, benign and slow-growing phosphaturic mesenchymal tumors.
D. Rendina, V. Abate, Giuseppe Cacace, L. D. Elia, G. De Filippo, S. Del Vecchio, F. Galletti, A. Cuocolo, P. Strazzullo   +8 more
semanticscholar   +1 more source

Osteomalacia as a Complication of Intravenous Iron Infusion: A Systematic Review of Case Reports

Journal of Bone and Mineral Research, 2022
Randomized control trials (RCTs) have shown that certain intravenous iron preparations can induce high levels of fibroblast growth factor 23 (FGF‐23) and persistent hypophosphatemia.
T. Vilaca, Nalini Velmurugan, Christopher D. Smith, B. Abrahamsen, R. Eastell   +4 more
semanticscholar   +1 more source

Osteomalacia in practice of endocrinologist: etiology, pathogenesis, differential diagnosis with osteoporosis [PDF]

Остеопороз и остеопатии, 2020
Osteoporosis is the most common cause of low bone mineral density (BMD) and low-traumatic fractures in adults. However, differential diagnosis should also consider other causes of decreased BMD, including osteomalacia, as treatment for these conditions ...
Olga O. Golounina, Gyuzel E. Runova, Valentin V. Fadeyev   +2 more
doaj   +1 more source

A Rare Case of Hypophosphataemic Osteomalacia in von Recklinghausen Neurofibromatosis

European Journal of Case Reports in Internal Medicine, 2021
Background: Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is a one of the more common hereditary autosomal disorders. However, osteomalacia in neurofibromatosis type 1 is very rare tumour-induced osteomalacia; fibroblast ...
Yasmine Makhlouf, Soumaya Boussaid, Houda Ajlani, Samia Jemmali, Sonia Rekik, Hela Sehli, Mouhamed Eleuch   +6 more
doaj   +1 more source

Osteomalacia Is Not a Single Disease

International Journal of Molecular Sciences, 2022
Among bone-material qualities, mineralization is pivotal in conferring stiffness and toughness to the bone. Osteomalacia, a disease ensuing from inadequate mineralization of the skeleton, is caused by different processes leading to decreased available ...
L. Cianferotti
semanticscholar   +1 more source