Results 91 to 100 of about 8,813 (214)

Perillyl alcohol promotes autophagy by suppressing the PI3K-AKT-mTOR signalling pathway in osteoarthritic chondrocytes in vitro

open access: yesScientific Reports
Osteoarthritis (OA) is a common degenerative disease characterized by chondrocyte death and extracellular matrix (ECM) degradation, but the present OA treatments are only symptomatic and not aetiologic.
Duo Zhao   +6 more
doaj   +1 more source

Evaluating the optimal duration of medication treatment for opioid use disorder

open access: yesAddiction, Volume 121, Issue 4, Page 922-933, April 2026.
Abstract Background and aims Clinicians have little guidance on the ideal length of time patients should remain on medication treatment for opioid use disorder (MOUD) before being able to safely discontinue MOUD. This study estimated how the risk of all‐cause mortality changes with the duration of MOUD, controlling for patient characteristics that ...
Corey J. Hayes   +5 more
wiley   +1 more source

“Food as Friend or Enemy”: A Qualitative Study of Motivations Underlying Restrictive Dietary Practices in Fibromyalgia

open access: yesJournal of Human Nutrition and Dietetics, Volume 39, Issue 2, April 2026.
ABSTRACT Introduction Despite the absence of official dietary guidelines for fibromyalgia, many patients adopt restrictive diets in an attempt to alleviate symptoms. Understanding their motivations and experiences is essential to inform patient‐centred care. Methods This qualitative study included 19 individuals with fibromyalgia who reported following
Laura Albaladejo   +5 more
wiley   +1 more source

Highly Aligned, Post‐Drawn Electrospun Nanofiber Yarns Fabricated via a Parallel‐Track System for Suture Materials

open access: yesAdvanced Materials Interfaces, Volume 13, Issue 5, 4 March 2026.
Highly aligned nanofiber yarns are fabricated using a parallel‐track electrospinning system with post‐drawing prior to deposition. This approach enables continuous production of nanoyarns with controlled alignment and enhanced mechanical properties. Mechanical performance, degradation behavior, and suture‐relevant handling characteristics are evaluated,
Dominique Hassinger   +4 more
wiley   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

Osteopathic treatment of infants with infantile colic/excessive crying: a prospective, multicentric, randomized controlled trial and nested observational trial

open access: yesBMC Pediatrics
Background Colic in infants is defined as excessive crying in an otherwise healthy and thriving baby. Colic is a common but poorly understood and often frustrating problem for caregivers.
Florian Schwerla   +6 more
doaj   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao   +6 more
wiley   +1 more source

Several occurrences of osteomyelitis in dinosaurs from a site in the Bauru Group, Cretaceous of Southeast Brazil

open access: yesThe Anatomical Record, Volume 309, Issue 3, Page 642-648, March 2026.
Abstract This study investigates the occurrence of osteomyelitis in non‐avian dinosaurs, focusing on the Ibirá locality, a site with a high incidence of this pathological condition. We analyzed six new osteopathic sauropod specimens from the Upper Cretaceous of Brazil.
Tito Aureliano   +3 more
wiley   +1 more source

STELLA‐FTD: Examination of a behavior change intervention for frontotemporal dementia family care partners

open access: yesAlzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 1, March 2026.
Abstract INTRODUCTION Frontotemporal dementia (FTD) is the most common dementia in people under age 60. Although FTD is often characterized by behavioral symptoms, few national interventions address management of these symptoms. Here we describe our protocol for Support via Technology: Living and Learning with Advancing FTD (STELLA‐FTD), an ...
Allison Lindauer   +7 more
wiley   +1 more source

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