Results 151 to 160 of about 47,470 (259)

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

open access: yesMedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang   +12 more
wiley   +1 more source

The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging. [PDF]

open access: yesJ Gerontol A Biol Sci Med Sci
Baltasar-Fernandez I   +36 more
europepmc   +1 more source

Exploratory XPS Evidence for Ca–N Environments at the Organic–Mineral Interface in Bone

open access: yesSurface and Interface Analysis, Volume 58, Issue 6, Page 369-374, June 2026.
ABSTRACT Bone derives its remarkable mechanical properties from the nanoscale relationship between its organic matrix and mineral components. While interfacial interactions are known to affect bone mechanics, direct evidence of chemical bonding at this interface has been lacking.
Richard Leslie Abel   +3 more
wiley   +1 more source

Cone Beam Computed Tomography of Bonejaws in Patients With Primary Osteoporosis: A Systematic Review. [PDF]

open access: yesCurr Osteoporos Rep
Frassineti I   +7 more
europepmc   +1 more source

Personalized‐Context‐Aware Age Gap: A New Multi‐Omics Measurement Based on Age‐Enhanced Model AOE‐Net for Aging Acceleration and Chronic Disease Risk Prediction

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Addressing systemic biases in traditional aging clocks, we introduce PAAG, a context‐aware multi‐omics metric derived from the pre‐trained AOE‐Net. PAAG accurately captures localized aging acceleration, demonstrating superior predictive power for chronic disease risks and clinical outcomes across diverse aging populations.
Feng‐Ao Wang   +12 more
wiley   +1 more source

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang   +5 more
wiley   +1 more source

Expanding Phenotype of GINS1 Deficiency: A Case Report and Review of the Literature

open access: yesClinical Genetics, Volume 109, Issue 6, Page 1076-1080, June 2026.
The authors present a novel case and review of individuals with GINS1 deficiency, causing severe growth restriction and combined immunodeficiency. Only the ninth case of this ultrarare disorder, it highlights the role of these variants in disease, glaucoma as a feature, and the possibility of immunodeficiency without infections in affected individuals.
Michael P. Mackley   +6 more
wiley   +1 more source

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