Results 321 to 330 of about 99,821 (371)

Osteopontin

Critical Reviews in Oral Biology & Medicine, 2000
Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. OPN is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell ...
J, Sodek, B, Ganss, M D, McKee
openaire   +2 more sources

Thrombin cleavage of osteopontin initiates osteopontin’s tumor‐promoting activity

Journal of Thrombosis and Haemostasis, 2022
Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α4 β1 and α9 β1 integrins.Thrombin cleavage-resistant OPNR153A knock-in (OPN-KI) mice were generated and compared to OPN ...
Sameera Peraramelli, Qi Zhou, Qin Zhou, Bettina Wanko, Lei Zhao, Toshihiko Nishimura, Thomas H. Leung, Seiya Mizuno, Mamoru Ito, Timothy Myles, Thomas M. Stulnig, John Morser, Lawrence L.K. Leung   +12 more
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Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice

Nephron Experimental Nephrology, 1999
Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several different integrins. While numerous activities have been ascribed to OPN in vitro, and several in vivo functions have been suggested for the molecule, including much attention focused recently on OPN in different pathologies, the actual role that the protein
S R, Rittling, D T, Denhardt
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Osteopontin and Mucosal Protection

Journal of Dental Research, 2006
Protection of mucosal tissues of the oral cavity, intestines, respiratory tract, and urogenital tract from the constant challenge of pathogens is achieved by the combined barrier function of the lining epithelia and specialized immune cells. Recent studies have indicated that osteopontin (OPN) has a pivotal role in the development of immune responses ...
J, Sodek, A Paes, Batista Da Silva, R, Zohar   +2 more
openaire   +2 more sources

Nanostructure, osteopontin, and mechanical properties of calcitic avian eggshell

Science Advances, 2018
The biomineral phase of avian eggshell is characterized at the nanostructure scale and correlated with functional properties. Avian (and formerly dinosaur) eggshells form a hard, protective biomineralized chamber for embryonic growth—an evolutionary ...
Dimitra Athanasiadou, Wenge Jiang, Dina Goldbaum   +2 more
exaly   +2 more sources

Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin

Calcified Tissue International, 2005
Ectopic calcification is a major cause of bioprosthetic heart valve failure. New therapeutic opportunities are offered by the growing understanding that ectopic calcification is an actively regulated process involving several key gene products. One of these products, osteopontin (OPN), is a glycosylated phosphoprotein previously shown to inhibit ...
Rachit, Ohri, Elyse, Tung, Rupak, Rajachar, Cecilia M, Giachelli   +3 more
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Osteopontin in cancer

Osteopontin (OPN) is a heavily post-translationally modified protein with a molecular weight of 44-70 kDa, depending on the degree of glycosylation. OPN is involved in various biological processes, including bone remodeling, immune response, cell adhesion, migration, and survival.
Alpana, Kumari, Dharambir, Kashyap, Vivek Kumar, Garg   +2 more
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Osteopontin, angiogenesis and multiple myeloma

Leukemia, 2005
The significance of Osteopontin (OPN) and angiogenesis in the pathogenesis and the progression of hematological malignancies is highlighted in a paper by Colla et al.1 In this article, Colla et al, expand their studies on bone marrow (BM) angiogenesis2, 3 in an attempt to describe the role of OPN in multiple myeloma (MM).
V, Cheriyath, M A, Hussein
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Osteopontin and colon cancer progression

Clinical & Experimental Metastasis, 2003
Human colon cancer affects nearly 150,000 patients and results in 60,000 deaths in the United States per year. Despite significant advances in the management of the colon cancer patient, little change in survival rates has been appreciated over the past 50 years. The primary cause of death relates to the development of distant metastases to organs such
Timothy J, Yeatman, Ann F, Chambers
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The cancer‐related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis

Journal of Cellular Physiology, 2019
Osteosarcomas are bone tumors that frequently metastasize to the lung. Aberrant expression of the transcription factor, runt‐related transcription factor 2 (RUNX2), is a key pathological feature in osteosarcoma and associated with loss of p53 and miR‐34 ...
Francisco Villanueva, Héctor F Araya, P. Briceño, Nelson Varela, A. Stevenson, Sofía Jerez, F. Tempio, J. Chnaiderman, Carola Perez, M. Villarroel, E. Concha, F. Khani, R. Thaler, F. Salazar-Onfray, G. Stein, A. V. van Wijnen, M. Galindo   +16 more
semanticscholar   +1 more source