Results 111 to 120 of about 48,647 (281)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Development and validation of a population-based prediction scale for osteoporotic fracture in the region of Valencia, Spain: the ESOSVAL-R study

BMC Public Health, 2010
Background Today, while there are effective drugs that reduce the risk of osteoporotic fracture, yet there are no broadly accepted criteria that can be used to estimate risks and decide who should receive treatment.
Fluixá Carlos, Pascual Manuel, Gil Vicente, Giner Vicente, Sanfélix-Gimeno Gabriel, Peiró Salvador, Sanfélix-Genovés José, Fuertes Antonio, Hurtado Isabel, Ferreros Inmaculada   +9 more
doaj   +1 more source

Targeted Regeneration of Bone in the Osteoporotic Human Femur

, 2011
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system.
Gerard R. Ridgway, Poole, KES, Kenneth E. S. Poole, Borggrefe, J, Paul M Mayhew, Treece, GM, Ridgway, GR, Paul M. Mayhew, Andrew H. Gee, Graham M Treece, Mayhew, PM, Gee, AH, Graham M. Treece, Andrew H Gee, Gerard R Ridgway, Jan Borggrefe, Kenneth E S Poole   +16 more
core   +1 more source

Identification of Frailty Subtypes in African American Adults With and Without Type 2 Diabetes: A Latent Class Analysis From the Jackson Heart Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To identify frailty subtypes among African American adults with and without diabetes. Methods This analysis included data from 3979 African American men and women who enrolled in the Jackson Heart Study at baseline (Exam1: 2000–2004). To identify frailty subtypes, we selected 25 age‐related deficits in health and functional outcomes as ...
Felicia R. Simpson, Mark A. Espeland, Alain G. Bertoni, Jai J. Legins, Torre S. Lloyd, Tanaiya A. Sumter   +5 more
wiley   +1 more source

Type 2 Diabetes Is Associated With Increased Complications and Mortality After Hip Fracture in Older Adults Aged 60 Years or Older

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes (T2D) is associated with increased hip fracture risk. We evaluated the impact of T2D on post‐hip fracture outcomes, which is less well described. Materials and Methods Individuals aged ≥ 60 years hospitalised for hip fractures between 2011 and 2020 were identified from the territory‐wide electronic health records of Hong ...
Xincheng Zou, Manju Chandran, Xi Xiong, Chi‐Ho Lee, Wing‐Sun Chow, Carol H. Y. Fong, Lawrence C. M. Lau, Ka‐Shing Cheung, Carlos K. H. Wong, Kathryn C. B. Tan, Yu‐Cho Woo, Karen S. L. Lam, David T. W. Lui   +12 more
wiley   +1 more source

The Relationship Between Health Related Quality of Life and Vertebral Fracture in Male Osteoporotic Patients

, 2005
Osteoporosis is the most prevalent metabolic bone disease in older people and osteoporotic fractures can be a major cause of morbidity. Vertebral fractures can adversely affect quality of life by causing pain, reducing physical function and mobility, and
Selmin Gülbahar, Sevinç Karcı, Elif Akalın, Özlen Peker, Özlem El, Serap Alper, Metin Manisalı, Canan Altay, Çiğdem Bircan, Funda Köroğlu   +9 more
core  

Three-year follow-up mortality rate in Malta [PDF]

, 2016
Introduction: Primary osteoporosis is a major factor in fragility hip fractures. The index fracture is loaded with morbidity and increased mortality in these very fragile patients. The aim of the study was to evaluate the mortality rate after 3 months, 1
Grech, Stephan, Cuschieri, Sarah
core  

The epidemiology of fractures in England

, 2008
Introduction: Fractures are a considerable public health burden in the United Kingdom but information on their epidemiology is limited. Objective: This study aims to estimate the true annual incidence and lifetime prevalence of fractures in England ...
Reckless, IP, Mindell, J.S., Reckless, I.P., Shelton, N.J., Donaldson, LJ, Donaldson, L.J., Scholes, S, Scholes, S., Mindell, JS, Shelton, NJ   +9 more
core   +1 more source

The Impact of Nutritional Status on Oral Health Outcomes and Management in Older Adults: A Systematic Review and Meta‐Analysis

Gerodontology, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis evaluated the relationship between nutritional status and the oral health of older adults (aged 75 years or older). The PECO focus question was, ‘What is the occurrence, association and impact of nutritional state on the oral health outcomes and its management in older adults?’ Methods A ...
Kittipit Srisanoi, Ines Wnuk, Sabrina Maniewicz, Gerry McKenna, Frauke Müller, Claudio Leles, Piero Papi, Jayne Woodside, Murali Srinivasan   +8 more
wiley   +1 more source

Systematic screening for age‐related comorbidities: Health care optimization among persons with HIV in an outpatient setting

HIV Medicine, EarlyView.
Abstract Background Age‐related comorbidities occur earlier and more frequently in people with HIV (PWH) than in the general population and have emerged as a key challenge in long‐term HIV care. Unfortunately, many of these conditions remain undiagnosed, and systematic screening in clinical practice remains limited.
Anna Katrine Haslund Roed, Anne‐Mette Lebech, Sabine Singh, Ole Kirk, Susanne Dam Nielsen   +4 more
wiley   +1 more source