Results 51 to 60 of about 299,351 (228)

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Association between cardiovascular health and osteoporotic fractures: a national population-based study

Scientific Reports
Osteoporotic fractures are a major public health concern, particularly among the aging population, as they significantly contribute to morbidity, mortality, and reduced quality of life.
Jun Ou, Tingting Wang, Ridan Lei, Mengting Sun, Xiaorui Ruan, Jianhui Wei, Jiabi Qin   +6 more
doaj   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Prognostic Nutritional Index in Patients with Both Vertebral and Non-Vertebral Osteoporotic Fractures [PDF]

Objective: The prognostic nutritional index (PNI) is an index used to evaluate the basic nutritional status of patients with osteoporosis. However, it is not yet clear whether PNI can be used as an indicator of osteoporotic fracture.
Fulya Bakılan, Gizem Sarıçimen, BAKILAN, FULYA, Saricimen, Gizem   +3 more
core   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Occult Posterior Pelvic Ring Fractures in Elderly Patients with Osteoporotic Pubic Rami Fractures

Journal of Orthopaedic Surgery, 2010
Purpose. To evaluate postoperative walking status of elderly patients with osteoporotic pubic rami fractures with or without posterior pelvic ring fractures. Methods.
Tak-Wing Lau, Frankie Leung
doaj   +1 more source

Refracture and mortality following hospitalization for severe osteoporotic fractures: The Fractos Study

JBMR Plus, 2021
Severe osteoporotic fractures (hip, proximal humerus, pelvic, vertebral and multiple rib fractures) carry an increased risk of mortality. This retrospective cohort study in the French national healthcare database aimed to estimate refracture and ...
Christian Roux, Thierry Thomas, Julien Paccou, Geoffray Bizouard, Anne Crochard, Emese Toth, Magali Lemaitre, Frédérique Maurel, Laure Perrin, Florence Tubach   +9 more
doaj   +1 more source

Oral Glucocorticoid Dose Patterns and Organ Damage in Systemic Lupus Erythematosus—A Nationwide Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective Evaluating the relationship between glucocorticoid (GC) exposure and organ damage in systemic lupus erythematosus (SLE) is challenging because GC dose varies over time. It is unclear which exposure time window captures the full impact of GC usage.
Annica Dominicus, Álvaro Gomez, Ngoc V. Nguyen, Karin Blomkvist Sporre, Francesca Faustini, Elisabet Svenungsson, Elizabeth V. Arkema   +6 more
wiley   +1 more source

Using vital statistics to estimate the population-level impact of osteoporotic fractures on mortality based on death certificates, with an application to France (2000-2004)

BMC Public Health, 2009
Background We developed a methodology using vital statistics to estimate the impact of osteoporotic fractures on the mortality of an entire population, and applied it to France for the period 2000-2004.
Jougla Eric, Ziadé Nelly, Coste Joël
doaj   +1 more source

A Transosseous Suture Technique for Rotator Cuff Repair in Patients With Severe Osteoporosis

Arthroscopy Techniques, EarlyView.
Abstract Suture anchor‐based repair is widely regarded as the standard technique for rotator cuff tears; however, in patients with severe osteoporosis, anchor pullout remains a major concern. Classical transosseous rotator cuff repair provides favorable biomechanical strength and avoids anchor‐related complications but has several inherent limitations.
Yujia Qiu, Jinyuan Xie, Mengyang He, Deng Chen, Zhangrui Wang, Liang Hu   +5 more
wiley   +1 more source