Results 61 to 70 of about 584,610 (216)

Denosumab discontinuation and fracture risk: getting the balance right

Internal Medicine Journal, EarlyView.
Abstract Denosumab is a highly effective therapy for osteoporosis. Since its approval by the Therapeutic Goods Administration (TGA) in 2010, use of denosumab has surged across Australia, delivering substantial fracture‐prevention benefits to tens of thousands of patients. However, stopping denosumab may lead to acute loss of bone with an increased risk
Albert S. Kim, Christian M. Girgis
wiley   +1 more source

Too Fit to Fracture: Exercise recommendations for individuals with osteoporosis or osteoporotic vertebral fracture [PDF]

, 2014
SUMMARY: A consensus process was conducted to develop exercise recommendations for individuals with osteoporosis or vertebral fractures. A multicomponent exercise program that includes balance and resistance training is recommended. INTRODUCTION: The aim
Laprade, J, McGill, S, Cheung, AM, MacIntyre, NJ, Shipp, K, Papaioannou, A, Wark, J, Giangregorio, LM, Heinonen, A, Ashe, MC, Keller, H, Jain, R   +11 more
core   +1 more source

SGLT2i use and fracture risk compared with DPP4i in patients with T2DM

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction The association between sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) use and fracture risk remains inconclusive. Most previous studies have focused on treatment‐naïve patients, despite many patients in routine clinical practice initiating SGLT2i therapy after prior dipeptidyl peptidase‐4 inhibitor (DPP4i) use.
Sung‐Yen Lin, Shih‐Hao Huang, Ching‐Han Chiang, Cheng‐Jung Ho, Chung‐Hwan Chen, Li‐Nien Chien   +5 more
wiley   +1 more source

Prognostic Nutritional Index in Patients with Both Vertebral and Non-Vertebral Osteoporotic Fractures [PDF]

Objective: The prognostic nutritional index (PNI) is an index used to evaluate the basic nutritional status of patients with osteoporosis. However, it is not yet clear whether PNI can be used as an indicator of osteoporotic fracture.
Fulya Bakılan, Gizem Sarıçimen, BAKILAN, FULYA, Saricimen, Gizem   +3 more
core   +1 more source

Kinetic of bone turnover markers after osteoporotic vertebral compression fractures in postmenopausal female

Journal of Orthopaedic Surgery and Research, 2018
Background Osteoporotic fracture occurs mostly at the spine, in which the commonest one is vertebral compression fracture. Bone turnover markers (BTMs) can be applied to assess bone formation and resorption activity.
Changyu Pan, Xiaoyang Liu, Tao Li, Guodong Wang, Jianmin Sun   +4 more
doaj   +1 more source

Reduced Circulating Levels of miR-491-5p and miR-485-3p Are Associated with the Occurrence of Vertebral Fractures in Postmenopausal Women with Osteoporosis

Genetics Research, 2022
Objective. Postmenopausal women experiences osteoporotic structural damage and bone fragility resulting from reduced bone formation and increased bone resorption. Osteoporosis frequently affects the vertebral column and causes compression fractures. This
Jixi Xu, Mingbo Li, Wei Pei, Jinyong Ding, Yueran Pan, Huifeng Peng, Shiman Lin, Yanbo Huang   +7 more
doaj   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

The Radiology of Osteoporotic Vertebral Fractures Revisited [PDF]

Journal of Bone and Mineral Research, 2019
ABSTRACT   Until recently there has been little evidence available to validate any method by which to make an accurate diagnosis of an osteoporotic vertebral fractures (OVFs) from plain radiographs. In part this reflects a lack of a completely satisfactory “gold standard,” but primarily it relates to ...
Lentle, BC, Koromani, Fjorda, Brown, JP, Oei, L, Ward, L, Goltzman, D, Rivadeneira, Fernando, Leslie, WD, Probyn, L, Prior, J, Hammond, I, Cheung, AM, Oei, Edwin   +12 more
openaire   +3 more sources

Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures [PDF]

, 2013
Insertion of bone substitution materials accelerates healing of osteoporotic fractures. Biodegradable materials are preferred for application in osteoporotic patients to avoid a second surgery for implant replacement. Degraded implant fragments are often
Vivien Kauschke, Hartmann, Sonja, Alexander Langheinrich, Matthias Schumacher, Matthias Schnabelrauch, Hanke, Thomas, Heiss, Christian, Olaf Kilian, Kauschke, Vivien, Sonja Hartmann, Christian Heiss, Alt, Volker, Heinemann, Sascha, Marian Kampschulte, Kilian, Olaf, Thormann, Ulrich, Lips, Katrin Susanne, Langheinrich, Alexander, Schumacher, Matthias, Michael Gelinsky, Armin R Kautz, Seemun Ray, Volker Alt, Kampschulte, Marian, Katrin Susanne Lips, Gelinsky, Michael, Ray, Seemun, Schnettler, Reinhard, Sascha Heinemann, Reinhard Schnettler, Ulrich Thormann, Schnabelrauch, Matthias, Kautz, Armin R., Thomas Hanke, Langheinrich Alexander, Ray Seemun, Schumacher Matthias, Kilian Olaf, Lips Katrin Susanne, Schnettler Reinhard, Hartmann Sonja, Heinemann Sascha, Heiss Christian, Kampschulte Marian, Thormann Ulrich, Schnabelrauch Matthias, Kautz Armin R., Kauschke Vivien, Alt Volker, Gelinsky Michael, Hanke Thomas   +50 more
core   +1 more source

IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse.

PLoS ONE, 2016
Osteoporosis is one of the most prevalent skeletal system diseases. It is characterized by a decrease in bone mass and microarchitectural changes in bone tissue that lead to an attenuation of bone resistance and susceptibility to fracture.
Xiang Li, Zong-Yu Zhou, Yuan-Yuan Zhang, Hui-Lin Yang   +3 more
doaj   +1 more source