Results 1 to 10 of about 1,382 (169)

Improving Hip Fracture Prediction by Using Sarcopenia-Specific Cut-Offs of T-Scores for Osteosarcopenia: A Prospective Cohort Study. [PDF]

J Cachexia Sarcopenia Muscle
Background Older adults with osteosarcopenia, defined as the coexistence of osteopenia/osteoporosis and sarcopenia, have been associated with an increased risk of fractures compared with those with normal bone mineral density (BMD) and without sarcopenia.
Lu AZ, Lam FMH, Leung J, Auyeung TW, Lee J, Lai KS, Woo J, Kwok T.   +7 more
europepmc   +3 more sources

The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives. [PDF]

Health Sci Rep
Background and Aims Osteosarcopenia, defined as the coexistence of osteoporosis and sarcopenia, is an emerging geriatric syndrome linked to the musculoskeletal decline associated with aging.
Taj J, Zafar R, Ekouo J, Junaid A, Makeda D, Latif K, Yokolo H.   +6 more
europepmc   +3 more sources

Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture

Journal of Orthopaedic Translation, 2023
Background: Osteosarcopenia is a syndrome coexisting sarcopenia and osteopenia/osteoporosis, with a high fracture risk. Recently, skeletal muscle and bone have been recognized as endocrine organs capable of communication through secreting myokines and ...
Jinyu Wang, Yun-Feng Rui, Yingjuan Li
exaly   +3 more sources

Osteosarcopenia is a potential predictor for the prognosis of patients who underwent hepatic resection for colorectal liver metastases

Annals of Gastroenterological Surgery, 2021
Aim We investigated the prognostic impact of osteosarcopenia, which is the combination of osteopenia and sarcopenia, in patients with colorectal liver metastases (CRLM) after hepatic resection.
Hironori Shiozaki, Toru Ikegami, Koichiro Haruki   +2 more
exaly   +2 more sources

Why Osteosarcopenia Matters: Clinical and Investigative Implications. [PDF]

Eur J Clin Invest
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Bonamigo EL, Maia MN, Pinheiro Cavallaro de Oliveira R, Gemerasca Mestriner R, Aprahamian I, Duque G.   +5 more
europepmc   +2 more sources

Association between stride length variability and osteosarcopenia in community-dwelling older women: a cross-sectional study. [PDF]

BMC Geriatr
Background Osteosarcopenia, the coexistence of sarcopenia and low bone mass, raises the risk of falls, fractures, and functional decline, yet its diagnosis depends on dual-energy X-ray absorptiometry (DXA) and muscle function testing, which are difficult
Jin Y, Han K, Kim D.
europepmc   +2 more sources

Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures. [PDF]

Exp Physiol
Abstract Older adults experience a markedly increased risk of falls and fractures following hospital discharge, largely due to the rapid musculoskeletal deterioration associated with bed rest. Although age‐related muscle and bone loss typically develops gradually, acute physical inactivity accelerates key biological processes underlying sarcopenia and ...
Reyes JM, Hajj-Boutros G, Rouabhia D, Morais J, Salech F, Duque G.   +5 more
europepmc   +2 more sources

Global epidemiological features and impact of osteosarcopenia: A comprehensive meta-analysis and systematic review

Journal of Cachexia, Sarcopenia and Muscle
Osteosarcopenia is defined as the concurrent occurrence of osteopenia/osteoporosis and sarcopenia. The aim of the current study was to perform a systematic review with meta‐analysis to determine the global prevalence, risk factors and clinical outcomes ...
Jianghua Zhou, Pan Huang, Huping Gong
exaly   +2 more sources

Impact of osteosarcopenia in older people on prognosis following major surgery: a scoping review. [PDF]

PeerJ
Purpose This review aims to map the existing literature on the prevalence, diagnostic criteria, and impact of osteosarcopenia on postoperative clinical outcomes in older adults.
Silva-Diaz YA, Odar-Rojas C, Pasten-Hidalgo W, Gallegos-Chavez E, Barros-Osorio C, Sepúlveda-Loyola W.   +5 more
europepmc   +3 more sources

Osteosarcopenia: key molecular mechanisms and translational perspectives. [PDF]

Front Physiol
The coexistence of osteoporosis and sarcopenia is recognized as a syndrome known as osteosarcopenia. As an aging-related disease, research into the molecular mechanisms of osteosarcopenia has gradually shifted from the study of single-organ pathology to ...
Pu Y, Teng Y, Li Y, Zhou Y, Gao M, Yan Z, Teng Z.   +6 more
europepmc   +2 more sources