Results 51 to 60 of about 1,255 (165)

Pain characterization in osteosarcopenia: an exploratory study. [PDF]

Front Rehabil Sci
Objective To characterize pain in terms of frequency, intensity, and correlation with nutritional status, muscle mass, and physical performance in osteosarcopenic patients. Method We included patients affected by osteosarcopenia (OSP),
Moretti A, Paoletta M, Fabrazzo FP, Liguori S, Airoma M, Tardugno M, Gimigliano F, Iolascon G.   +7 more
europepmc   +4 more sources

Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice

Aging Cell, Volume 25, Issue 8, August 2026.
Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez, Alejandra Valle‐Cao, Francisco Rodríguez, Manuel Fernández‐Sanjurjo, Benjamín Fernández‐García, Vanessa Loredo, María Teresa Fernández‐García, Carmen Fiuza‐Luces, Alejandro Lucia, Carlos López‐Otín, Alejandro López‐Soto, Alicia R. Folgueras   +11 more
wiley   +1 more source

Osteosarcopenia in rheumatoid arthritis treated with glucocorticosteroids – essence, significance, consequences

Rheumatology, 2020
Rheumatoid arthritis (RA) is one of the most common rheumatic diseases, associated with cooccurrence of serious side effects. This study discusses the problems associated with chronic RA, well-known as osteoporosis, but also recently recognized as ...
Marcin Radkowski, Piotr Sławiński, Tomasz Targowski   +2 more
doaj   +1 more source

Does osteosarcopenia shorten life? [PDF]

Rev Assoc Med Bras (1992)
Forni JEN.
europepmc   +4 more sources

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data

Aging Cell, Volume 25, Issue 7, July 2026.
This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from the UK Biobank. Our findings indicated that the two conditions may act as reciprocal risk factors, with multiple potential biomarkers mediating the muscle‐bone relationship and suggested possible shared signals between the ...
Siqi Xu, Simin Wen, Xizeng Zong, Jianwei Zhu, Qiuling Du, Yu Li, Kunyan Wang, Peihua Cao, Changhai Ding, Yan Zhang, Guangfeng Ruan   +10 more
wiley   +1 more source

Osteosarcopenia: epidemiology, molecular mechanisms, and management. [PDF]

Front Endocrinol (Lausanne)
Osteosarcopenia (OS), a recently recognized syndrome characterized by the simultaneous occurrence of osteopenia/osteoporosis and sarcopenia, has emerged as an important concept in clinical practice. This integrated framework provides a comprehensive view of the musculoskeletal system, addressing a previously underappreciated aspect of muscle health. OS
Yi YT, Zhao HF, Wang WZ, Li X.
europepmc   +3 more sources

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1235-1247, June 2026.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

Disability, Frailty and Depression in the community-dwelling older adults with Osteosarcopenia

BMC Geriatrics, 2021
Background The purpose of this study was to investigate the prevalence of osteosarcopenia in the over 60-year-old community and to evaluate whether osteosarcopenia is associated with disability, frailty and depression.
Ki-Soo Park, Gyeong-Ye Lee, Young-Mi Seo, Sung-Hyo Seo, Jun-Il Yoo   +4 more
doaj   +1 more source

Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications

Journal of Functional Morphology and Kinesiology, 2021
Bone and muscle tissues influence each other through the integration of mechanical and biochemical signals, giving rise to bone–muscle crosstalk. They are also known to secrete osteokines, myokines, and cytokines into the circulation, influencing the ...
Ida Cariati, Roberto Bonanni, Federica Onorato, Ambra Mastrogregori, Danilo Rossi, Riccardo Iundusi, Elena Gasbarra, Virginia Tancredi, Umberto Tarantino   +8 more
doaj   +1 more source

From Pixels to Prediction: Reviewing the Role of Artificial Intelligence in Body Composition Analysis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Evaluation of body composition (BC) is a set of biomarkers, including fat, muscle and bone, that allows the quantification of an individual's composition at different levels of complexity (whole body, tissues, macroscopic and microscopic). Recently, BC has gained medical interest due to its impact on health outcomes in both oncologic and non ...
Marta Zerunian, Benedetta Masci, Stefano Nardacci, Federico Perconti, Lapo Nardoni, Vincenzo Solimene, Michela Polici, Francesco Pucciarelli, Tiziano Polidori, Domenico De Santis, Andrea Laghi, Damiano Caruso   +11 more
wiley   +1 more source