Results 131 to 140 of about 4,215 (173)

Proteoglycans in Breast Cancer: Friends and Foes. [PDF]

Biomolecules
Vigo-Díaz N, López-Cortés R, Velo-Heleno I, Rodríguez-Silva L, Núñez C.   +4 more
europepmc   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Genetic Variants Associated with Non-Steroidal Anti-Inflammatory Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. [PDF]

Med Sci (Basel)
Kosanlawit J, Konyoung P, Amornpinyo W, Tassaneeyakul W, Kanjanawart S, Pattanacheewapull O, Purimart D, Nakkam N.   +7 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Dynamic OGTT-derived C-peptide trajectories for metabolic heterogeneity and adverse pregnancy outcomes in gestational diabetes mellitus: a nested case‒control study. [PDF]

BMC Med
Wang X, He Z, Ji J, Zhang S, Li J, Zhang J, Yu W, Yang H, Han Z, Mi Y, Luo X.   +10 more
europepmc   +1 more source

Large‐Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

Journal of Clinical Laboratory Analysis, EarlyView.
Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou, Shandra Jones, Juan Montes, Jonathan Ritter, Li‐Yu Shih, Chia‐Jung Chan, Ying‐Chou Lin, Min Chen, Shih‐Yin Chen, Ning Wu   +9 more
wiley   +1 more source

Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir. [PDF]

Sci Adv
Baranovskiy AG, He Q, Suwa Y, Morstadt LM, Babayeva ND, Lim CJ, Tahirov TH.   +6 more
europepmc   +1 more source

Longitudinal Changes in the Serum Pepsinogen I/II Ratio With Progression of Gastric Atrophy

Journal of Clinical Laboratory Analysis, EarlyView.
Serum pepsinogen (PG) I/II ratio decreased with progression of gastric mucosal atrophy and showed consistent intra‐individual changes over time. In a large cohort with repeated endoscopic evaluations, longitudinal declines in the PG I/II ratio paralleled worsening atrophic stages.
Soie Chung, Jung Kim, Ji Hyun Song, Jooyoung Lee, Sun Young Yang, Eun Young Song   +5 more
wiley   +1 more source

Plasma Very‐Long‐Chain Fatty Acids in X‐Linked Adrenoleukodystrophy: Diagnostic Insights From a Clinical Laboratory Cohort

Journal of Clinical Laboratory Analysis, EarlyView.
Plasma VLCFA levels are increased in symptomatic X‐linked adrenoleukodystrophy, particularly in patients with cerebral involvement. However, they do not reliably predict disease progression or longitudinal changes. These findings support their diagnostic value while highlighting the need for more robust prognostic biomarkers in clinical practice ...
Sergio Molina Blas, Sergio Pérez Pujalte, Ana Moreno Álvarez, Ana Isabel Álvarez Ríos, Beatriz Muñoz Cabello, Constanza Navarro Moreno, Ana Lucia Gómez Gila, Elena Dios Fuentes, Eva Venegas Moreno, Carmen Delgado Pecellín   +9 more
wiley   +1 more source

Exploring the relationships between the gut microbiome composition and movement patterns of laying hens in a multitier cage-free housing system. [PDF]

PLoS One
Cazals A, Gebhardt-Henrich S, Berger Q, Rossignol MN, Jardet D, Toscano MJ, Zerjal T.   +6 more
europepmc   +1 more source