Results 191 to 200 of about 268,026 (223)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Probing Antibiotic Inhibition in Small Bacterial Populations With Combinatorial Droplet Microfluidics. [PDF]

Small Sci
Samimi A, Verdon N, Allen RJ, Rosenbaum MA.   +3 more
europepmc   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

A Genus Comparison in the Topological Analysis of RNA Structures. [PDF]

Acta Biotheor
Cangiotti N, Grasso S.
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Probabilistic greedy algorithm solver using magnetic tunneling junctions for traveling salesman problem. [PDF]

Nat Commun
Zhang R, Li X, Wan C, Hoffmann R, Hindenberg M, Xu Y, Liu S, Kong D, Xiong S, He S, Vardar A, Dai Q, Gong J, Sun Y, Zheng Z, Kämpfe T, Yu G, Han X.   +17 more
europepmc   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

LAFS: A Fast, Differentiable Approach to Feature Selection Using Learnable Attention. [PDF]

Entropy (Basel)
Topçuoğlu H, Evren A, Tuna E, Ustaoğlu E.   +3 more
europepmc   +1 more source

Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state. [PDF]

Sci Adv
Arutyunyan A, Seuma M, Faure AJ, Bolognesi B, Lehner B.   +4 more
europepmc   +1 more source

Multistable thin-shell metastructures for multiresponsive reconfigurable metabots. [PDF]

Sci Adv
Zhou C, Qing H, Sun H, Qi F, Hong Y, Yin J.   +5 more
europepmc   +1 more source