Results 131 to 140 of about 48,533 (272)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Sound insulation of flow-permeable biomimetic honeycomb structures with Helmholtz resonators
Discover Mechanical EngineeringEffective low-frequency noise control in ventilated systems is a significant engineering challenge due to the trade-off between airflow and sound insulation.
N. V. David +4 more
doaj +1 more source
Constraint Management on Distributed Design Configurations
, 1993 Architecture, Engineering and Construction (AEC) design processes involve the participation of many designers who may be working independently in geographically distinct locations.
Sanjai Tiwari, Ashish Gupta
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
On the algorithmic design of architectural configurations
The algorithmic design of an architectural configuration depends on one’s ability to compare the merit of different solutions quantitatively, in order to decide which design is superior.
Oded Fuhrmann, Craig Gotsman
core
The aerodynamic design and optimization of a wing-fuselage junction fillet as part of a multi-disciplinary optimization process during the early aircraft design stages [PDF]
, 1996 An attempt to minimize interference drag in a wing-fuselage junction by means of inserting a fillet is presented in this thesis. The case of a low-wing com- mercial transport aicraft at cruise conditions is examined.
Hadjiilias, Hippokrates A. +1 more
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