Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Capabilities in the Context of Education and Whole-Day Schooling: The Situation in Poland
The project: Capabilities in the context of education and whole-day schooling co-ordinated by the University of Bielefeld, which this expertise is prepared for, is aimed at: discussion of different models of integrating education (Bildung), bringing
Tomasz Szkudlarek, Maria Mendel
doaj +2 more sources
Twenty Years of Microtron Laboratory Activities at CTU in Prague
I for medical diagnostic purposes), et cetera. Participation of the microtron laboratory in the education of students of the faculty in various fields of applied dosimetry and other microtron applications is also discussed.
M. Vognar, Č. Šimáně, D. Chvátil
doaj
Teaching and Testing EFL in Iran: Global Trends and Local Dilemmas [PDF]
Beginning the second half of the last century, language education has witnessed remarkable advancements and reforms that have profoundly influenced the principles and procedures of both teaching and testing.
Hossein Frahady
doaj
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Comparison of normalized gain and Cohen’s d for analyzing gains on concept inventories
Measuring student learning is a complicated but necessary task for understanding the effectiveness of instruction and issues of equity in college science, technology, engineering, and mathematics (STEM) courses.
Jayson M. Nissen +3 more
doaj +1 more source
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
The Association of University Professors of Ophthalmology and the Americanb Academy of Ophthalmology have jointly awarded Dr. Nicholas Volpe with the inaugural Straatsma Award for Excellence in Resident Education, in honor of his commitment to residency training in ophthalmology and other contributions to the field [PDF]
openalex +1 more source

