Results 51 to 60 of about 310,605 (260)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Self-learning AI in Educational Research and Other Fields

Research on Intelligent Manufacturing and Assembly
There are several areas where self-learning AI is actively used. Machine learning and deep learning allow you to identify patterns and improve performance. Algorithms such as neural networks can adapt and improve based on experience. Self-learning GPTs are used to dialogue with humans. Computer vision recognizes and classifies images.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Editorial: Entrepreneurship Education

Horyzonty Wychowania, 2014
Education plays a key role in shaping the attitudes, skills and culture, hence the actions of the European Union in recent years have aimed at promoting entrepreneurship as a separate course taught at all levels of education, from elementary up to the ...
Krzysztof Wach
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A metric profile of research highlighting teacher training in Science Education in Brazil

Investigações em Ensino de Ciências, 2019
This paper focuses on what current literature indicates about the need to learn about the teacher training research field in a wide-ranging and profound manner. Within this framework, the objective was to outline a metric profile of the research field of
Julio César Castilho Razera, Carla Maria Santana Matos, Fernando Bastos   +2 more
doaj   +1 more source

Open-Closed Mindedness of Students in Teacher Education and in Other College Fields

, 1971
Purpose of the Study This study sought to determine if teacher education students in two institutions of higher education were more authoritarian or closed minded than students in other fields of study . In addition, the study was designed to explore the relationship of other variables--sex, religious affiliation, church attendance, and city size and ...
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Merit Pay and Social Work

Social Work and Society, 2011
An economization of many social fields in Germany and other countries is under way, such as in the arts, journalism, education and science. Economic considerations have the upper hand in academic education (e.g., the introduction of tuition fees), while ...
Ursula H. Werling
doaj   +2 more sources