Results 111 to 120 of about 269,750 (295)

Formation of Attention as a Condition of Overcoming Phonemic Disorders in Children of Late Pre-School Age with General Speech Undevelopment

Российский психологический журнал, 2016
The paper studies characteristics of phonemic processes in children with general speech underdevelopment and their correction through the development of attention. Impairments in the discrimination of sense-distinctive characteristics of sounds(phonemes) 
Tat’iana V. Korotovskikh, Iuliia S. Piashkur   +1 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Generalized charges, part I: Invertible symmetries and higher representations

SciPost Physics
$q$-charges describe the possible actions of a generalized symmetry on $q$-dimensional operators. In Part I of this series of papers, we describe $q$-charges for invertible symmetries; while the discussion of $q$-charges for non-invertible symmetries is ...
Lakshya Bhardwaj, Sakura Schäfer-Nameki
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Comparing apples with apples: A proposed taxonomy for "Community Health Workers" and other front-line health workers for international comparisons.

PLOS Global Public Health
This paper proposes a taxonomy for Community Health Workers (CHWs) and others engaged in front-line community health activities, encompassing formally-employed workers extending government primary health care (PHC) service delivery as well as a range of ...
Stephen Hodgins, Uta Lehmann, Henry Perry, Nicholas Leydon, Kerry Scott, Smisha Agarwal, Hannah Marcus, Rajani Ved, Elijah Olivas, Madeleine Ballard, Dickson Mbewe, Margaret Odera, Sherlie Petit Homme, Benard Otieno, Pasipano Wutete, Angeline Chikumba, Prossy Muyingo, John Kyakuha, Emmanuel Harcourt, Morseda Chowdhury, David Musoke, Thadee Niyoyitungira, Abimbola Olaniran, John Koku-Awoonor Williams, Lívia Milena Barbosa de Deus E Méllo, Romário Correia Dos Santos, Isabela Cardoso de Matos Pinto, Ram Shrestha, Salim Sadruddin, Melanie Morrow, Eric Sarriot, Maryse Kok, Bhanu Pratap   +32 more
doaj   +1 more source

A Framework for Non-Gaussian Functional Integrals with Applications

, 2019
Functional integrals can be defined in terms of families of locally compact topological groups and their associated Banach-valued Haar integrals. The definition forgoes the goal of constructing a genuine measure on the domain of integration, but instead ...
LaChapelle, J.
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Toxicity and Risk of Biopesticides to Insect Pollinators in Urban and Agricultural Landscapes

Agrochemicals
Pollinators play important roles in providing pollination services, maintaining biodiversity, and boosting crop production. Even though pollinators are essential to the environment and agriculture, their decline has been noted across multiple studies in ...
Joshua Chavana, Neelendra K. Joshi
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source