Results 151 to 160 of about 269,750 (295)

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

INNOVATIVE TRENDS IN VOCATIONAL TEACHER EDUCATION: A CAREER COUNSELOR FOR THE NEW UKRAINIAN SCHOOL

open access: yesНеперервна професійна освіта: теорія та практика
The article considers the problem of training career counselors for the New Ukrainian School as a modern innovative trend. It is updated in the context of the introduction of three-year specialized education in Ukraine.
Liudmyla Khoruzha   +2 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

PROCEDURAL LAW AND PLURALISM. DISADVANTAGED GROUPS OF PEOPLE AND AN APPROACH TO LITIGATION STEMMING FROM LAND DISPOSSESSION AND FORCED DISPLACEMENT. HOW TO SETTLE PRIVATE (NON-STATE) LAND DISPUTES INVOLVING MEMBERS OF INDIGENOUS AND OTHER DISADVANTAGED GROUPS IN A JUST WAY WHILE GUARANTEEING DUE PROCESS OF LAW? GENERAL REPORT

open access: yesRevista Eletrônica de Direito Processual, 2016
The author advocates the establishment, by the law, of special courts and procedures for the prosecution and adjudication of legal claims arising from land dispossession and forced displacement suffered by indigenous peoples and other disadvantaged groups, considering the legal, cultural and linguistic specificities of these cases, as a way to ...
openaire   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

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