Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
INNOVATIVE TRENDS IN VOCATIONAL TEACHER EDUCATION: A CAREER COUNSELOR FOR THE NEW UKRAINIAN SCHOOL
The article considers the problem of training career counselors for the New Ukrainian School as a modern innovative trend. It is updated in the context of the introduction of three-year specialized education in Ukraine.
Liudmyla Khoruzha +2 more
doaj +1 more source
The racial and ethnic gap in behavioral measures rivals the gender gap in the United States. [PDF]
Dariel A +3 more
europepmc +1 more source
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Marginal link between sociality and gut microbiome in disparate mammalian hosts. [PDF]
Lebeuf-Taylor E, Cottenie K.
europepmc +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Developmental differences in hippocampal long-axis contributions to memory precision. [PDF]
Vijayarajah S, Schlichting ML.
europepmc +1 more source
Groups generated by two operators each of which is transformed into a power of itself by the square of the other [PDF]
openaire +2 more sources
The author advocates the establishment, by the law, of special courts and procedures for the prosecution and adjudication of legal claims arising from land dispossession and forced displacement suffered by indigenous peoples and other disadvantaged groups, considering the legal, cultural and linguistic specificities of these cases, as a way to ...
openaire +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source

