Results 161 to 170 of about 2,310,738 (305)

Beyond reproduction: The ovary as a systemic regulator of female health and aging. [PDF]

PLoS Biol
Garrison JL.
europepmc   +1 more source

A Comparison Study on Characteristics of Research Output in Life Sciences and Other Sciences Through Analysis of KOSEF's Database [PDF]

Journal of Animal Science and Technology, 2006
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The impact of COVID-19 on longevity trends and disparities among Native Americans and Whites in the Four Corners States. [PDF]

PLoS One
Lenarz AM, Park H, Roberts MT, Pan A, Hofmann ET, Reither EN.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Maakasutuse ja põllumajanduspraktikate mõju vihmaussikooslustele ja mulla kvaliteedile

Doctoral Thesis in Agriculture.Doktoritöö põllumajanduses.ABSTRACT. The loss of soil biodiversity is considered one of the greatest threats to soil functioning in Europe. Due to their significant role in the soil, their abundance is considered one of the
Sutri, Merit
core   +1 more source

Characterization of discontinuous ventilation cycles in nymphal Ixodes scapularis. [PDF]

PLoS One
Schofield S, Waters JS, D Y Bandara YMN, Couret J.   +3 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Do you want to live forever? Lessons learned from the biology of aging. [PDF]

PLoS Biol
Mair WB, Alvarez-Garcia I.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source