Results 221 to 230 of about 37,538,770 (286)

Convergent evolution of viral nucleases targeting cyclic dinucleotides. [PDF]

PLoS Pathog
Li Z, Zhang L.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Global plastics treaty negotiations and health-care system use of plastics, WHO African Region. [PDF]

Bull World Health Organ
Egbewande OM, Okediji OE, Adeboye AS.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Author Correction: Single-cell profiling decodes patagium development in gliding mammal. [PDF]

Nat Commun
Lin Y, Huang S, Che L, Zhao H, Wang Y, Yang M, Ai C, Ruan J, Wang X, Yu L.   +9 more
europepmc   +1 more source

Is there already value in "total body PET" imaging in neurology? [PDF]

Br J Radiol
Hammers A.
europepmc   +1 more source

Polypharmacy and quality of life in Yemeni cancer patients undergoing chemotherapy: A cross-sectional study. [PDF]

PLOS Glob Public Health
Al-Jamei S, Al-Ansi H, Albiel M, Al-Awadhi E, Jihad S, Noman A, Alhayani F, Alarhabi R.   +7 more
europepmc   +1 more source

Extending Trait-Based Ecology Across Disciplines in the Face of Global Change. [PDF]

Ecol Evol
Gonçalves-Souza T, Au TF, Brinkhoff RE, McPherson MR, Raubenheimer SL, Rocci KS, Song Y, Zheng L, Head JR, Chen X, Bardou R, Reich PB.   +11 more
europepmc   +1 more source