Results 71 to 80 of about 1,183,522 (244)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

More Numerically Accurate Algorithm for Stiff Matrix Exponential

Mathematics
In this paper, we propose a novel, highly accurate numerical algorithm for matrix exponentials (MEs). The algorithm is based on approximating Putzer’s algorithm by analytically solving the ordinary differential equation (ODE)-based coefficients and ...
Teddy Lazebnik, Svetlana Bunimovich-Mendrazitsky   +1 more
doaj   +1 more source

A quantum algorithm for linear autonomous differential equations via Padé approximation [PDF]

Quantum
We propose a novel quantum algorithm for solving linear autonomous ordinary differential equations (ODEs) using the Padé approximation. For linear autonomous ODEs, the discretized solution can be represented by a product of matrix exponentials.
Dekuan Dong, Yingzhou Li, Jungong Xue
doaj   +1 more source

Strong Scaling of Matrix Multiplication Algorithms and Memory-Independent Communication Lower Bounds [PDF]

, 2012
A parallel algorithm has perfect strong scaling if its running time on P processors is linear in 1/P, including all communication costs. Distributed-memory parallel algorithms for matrix multiplication with perfect strong scaling have only recently been ...
Ballard, Grey, Demmel, James, Holtz, Olga, Lipshitz, Benjamin, Schwartz, Oded   +4 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

A Kernel Gabor-Based Weighted Region Covariance Matrix for Face Recognition

Sensors, 2012
This paper proposes a novel image region descriptor for face recognition, named kernel Gabor-based weighted region covariance matrix (KGWRCM). As different parts are different effectual in characterizing and recognizing faces, we construct a weighting ...
Yantao Li, Lian Xue, Huafeng Qin, Lan Qin   +3 more
doaj   +1 more source

Cooperative Localization under Limited Connectivity

, 2019
We report two decentralized multi-agent cooperative localization algorithms in which, to reduce the communication cost, inter-agent state estimate correlations are not maintained but accounted for implicitly.
Kia, Solmaz S., Zhu, Jianan
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source