Results 171 to 180 of about 3,457,278 (273)

Emergency presentation of colorectal cancer in Africa: a scoping review. [PDF]

BMJ Open
Chinyowa S, Murewanhema G, Katsidzira L, Moodley J, Chirenje M, Muguti G.   +5 more
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

User experience and safety of generative AI-based mental health chatbots: Scoping review protocol. [PDF]

PLoS One
Olisaeloka L, Richardson C, Vigo D.
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Progress towards global elimination of lymphatic filariasis

The Lancet Global Health, 2020
Joseph Kamgno, Hugues Nana Djeunga
doaj   +1 more source

Distinct brain pathways link depressive symptoms due to respiratory dysfunction and reduced physical activity in patients with chronic obstructive pulmonary disease: A single-center observational pilot study. [PDF]

PLoS One
Sakakura S, Honma M, Masaoka Y, Manabe R, Okuda K, Yoshida M, Yoshikawa A, Matsui M, Shoji D, Kosuge M, Kosuge S, Miyo K, Ida M, Yamaguchi F, Yokoe T, Izumizaki M.   +15 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Increased Burden of Morbidity Over the Life-Course Among Patients with COPD: A Register-Based Cohort Study in Sweden

International Journal of COPD
Carolina Smith,1,2 Ayako Hiyoshi,1,3 Mikael Hasselgren,2,4 Hanna Sandelowsky,5– 7 Björn Ställberg,8 Scott Montgomery1,5,9 1Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro ...
Smith C, Hiyoshi A, Hasselgren M, Sandelowsky H, Ställberg B, Montgomery S   +5 more
doaj  

Evaluating the perceived outcome and impact of an integrated knowledge translation approach in the development of an equity reporting guideline: A cross-sectional survey. [PDF]

PLOS Glob Public Health
Brown J, Dewidar O, Chamberlain C, Cuervo LG, Ellingwood HN, Faber S, Feng C, Francis DK, Funnell S, Ghogomu E, Hardy BJ, Horsley T, Kasonde M, Kennedy M, Kredo T, Little J, Mahande MJ, Marshall Z, Mbuagbaw L, Nkangu M, Obuku EA, Oloyede O, Owusu-Addo E, Pantoja T, Pottie K, Rizvi A, Shamseer L, Shea B, Tufte J, Tugwell P, Bhutta Z, Wiysonge CS, Wolfenden L, Jull J, Welch V.   +34 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source