Results 71 to 80 of about 2,511 (218)
Contribuições sobre a utilização de funções de aproximação contínuas no método generalizado de elementos finitos: avaliação em mecânica da fratura [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópólis, 2012.Procedimentos de discretização que promovem o enriquecimento de subespaços de aproximação, para a solução
Torres, Diego Amadeu Furtado
core
On variational problems and optimization
, 2023 The Calculus of Variations is a mathematical field that tries to find the functions that minimize or maximize the value of certain functional defined on a determined space.
Rodríguez Llave, Laura María
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Techniques for solving nonlinear optimal control problems [PDF]
, 2015 This dissertation is a study of problem-solving techniques for optimization problems, and considers both theoretical and practical issues. Theoretical approaches based on the dynamical systems and corresponding cost criteria are developed, and efficient ...
Han, Seung Hak
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Existence theorem for solitary waves on lattices
, 1994 In this article we give an existence theorem for localized travelling wave solutions on one-dimensional lattices with Hamiltonian {Mathematical expression} where V(·) is the potential energy due to nearest-neighbour interactions.
Gero Friesecke +3 more
core +1 more source
Numerical Tools for Geometric Optimal Control and the Julia control-toolbox package
Ivan Kupka (1937-2023)International audienceWe present in this article numerical techniques — the Julia control-toolbox package — for computing geometric optimal control concepts: Hamiltonian flows associated to the optimal control problem, Jacobi flows,
Cots, Olivier, Gergaud, Joseph
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source