Results 21 to 30 of about 311,089 (206)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On The Development Of Finite Volume Methods For Computational Solid Mechanics [PDF]
, 2007 Since its initial development as a tool for structural analysis around the mid-fifties the Finite Element Method (FEM) has evolved to become the most popular and used method in modern Computational Solid Mechanics.
Idelsohn, Sergio Rodolfo +1 more
core
Bottom changes in coastal areas with complex shorelines [PDF]
, 2017 A model for the sea-bottom change simulations in coastal areas with complex shorelines is proposed. In deep and intermediate water depths, the hydrodynamic quantities are calculated by numerically integrating the contravariant Boussinesq equations ...
Cannata, Giovanni +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Российский технологический журналObjectives. This paper investigates the gravitational potential of a viscoelastic planet moving in the gravitational field of a massive attracting center (star), a satellite and one or more other planets moving in Keplerian elliptical orbits relative to ...
А. V. Shatina, A. S. Borets
doaj +1 more source
Self-supporting structure design in additive manufacturing through explicit topology optimization
, 2017 One of the challenging issues in additive manufacturing (AM) oriented topology optimization is how to design structures that are self-supportive in a manufacture process without introducing additional supporting materials. In the present contribution, it
Du, Zongliang +5 more
core +1 more source
A node-based smoothed conforming point interpolation method (NS-CPIM) for elasticity problems [PDF]
, 2011 This paper formulates a node-based smoothed conforming point interpolation method (NS-CPIM) for solid mechanics. In the proposed NS-CPIM, the higher order conforming PIM shape functions (CPIM) have been constructed to produce a continuous and piecewise ...
Liu G. R. +7 more
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Plane shear flows of frictionless spheres: Kinetic theory and 3D soft-sphere discrete element method simulations [PDF]
, 2014 We use existing 3D Discrete Element simulations of simple shear flows of spheres to evaluate the radial distribution function at contact that enables kinetic theory to correctly predict the pressure and the shear stress, for different values of the ...
Berzi, Diego +3 more
core +5 more sources