Results 161 to 170 of about 3,913,903 (385)

An Environmental Science and Engineering Framework for Combating Antimicrobial Resistance [PDF]

, 2018
On June 20, 2017, members of the environmental engineering and science (EES) community convened at the Association of Environmental Engineering and Science Professors (AEESP) Biennial Conference for a workshop on antimicrobial resistance.
Alcalde, Reinaldo E., Alvarez, Pedro J.J., Ashbolt, Nicholas, Bischel, Heather, Capiro, Natalie L., Crossette, Emily, Frigon, Dominic, Grimes, Kassandra, Haas, Charles N., Ikuma, Kaoru, Kappell, Anthony D., Kimbell, Lee K., LaPara, Timothy M., Li, Mengyan, Li, Xu, McNamara, Patrick J., Navab-Daneshmand, Tala, Pruden, Amy, Raskin, Lutgarde, Riquelme, Maria Virginia, Seo, Youngwoo, Sobsey, Mark D., Sozzi, Emanuele, Vikesland, Peter, Wigginton, Krista, Zhou, Zhi   +25 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Mechanism of Salvia miltiorrhiza in the treatment of periodontitis: integrative analyses via network pharmacology, molecular dynamics, and cellular assays

BMC Complementary Medicine and Therapies
Background Periodontitis is the primary cause of tooth loss in adults and is associated with cardiovascular disorders and type 2 diabetes, etc., significantly impairing patients’ quality of life. Salvia miltiorrhiza(S.
Yabing Chen, Siyu Du, Yijing Guo, Yi Zheng, Lei Wang   +4 more
doaj   +1 more source

Coronavirus (Covid-19) and other Diseases in Human Respiratory System Cure by Sputum Therapy Self Made Medicine [PDF]

, 2021
Pijush Kanti Bhattacharjee
openalex  

Stemming the Global Trade in Falsified and Substandard Medicines [PDF]

, 2013
Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and ...
Buckley, Gillian J., Gostin, Lawrence O., Kelley, Patrick W.   +2 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Mapping evidence of spinal manipulation therapy for headaches in South Africa: a scoping review of grey literature

BMC Complementary Medicine and Therapies
Objective Spinal manipulative therapy (SMT) has been demonstrated to be an effective management approach for primary headaches; however, current literature often excludes data from South Africa (SA). The use of grey literature provides a viable mechanism
Keseri Padayachy, Ismail Fatima, Morris Kahere, Alister du Rose, Katherine A. Pohlman   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Leonurine (SCM-198) exerts protective effects on pancreatic β-cells in type 1 diabetes by modulating the Bax/Bcl-2/Caspase-3 signaling pathway

BMC Complementary Medicine and Therapies
Background Type 1 diabetes mellitus (T1DM) is a disease marked by insulin deficiency and hyperglycemia, resulting from the destruction of pancreatic β-cells. The progression of T1DM is significantly influenced by oxidative stress and apoptosis.
Zhiqi Li, XiaoRan Liu, FuJiang Wen, WenGuo Jiang, ZhenHong Xia   +4 more
doaj   +1 more source

Mobile satellite services for public safety, disaster mitigation and disaster medicine [PDF]

Between 1967 and 1987 nearly three million lives were lost and property damage of $25 to $100 billion resulted form natural disasters that adversely affected more than 829 million people.
Freibaum, Jerry
core   +1 more source