Results 281 to 290 of about 6,287,948 (363)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

An Intervention to Increase Advance Care Planning Among Older Adults With Advanced Cancer: A Randomized Clinical Trial.

JAMA Netw Open
Volandes AE, Chang Y, Lakin JR, Paasche-Orlow MK, Lindvall C, Zupanc SN, Martins-Welch D, Carney MT, Burns EA, Itty J, Emmert-Tangredi K, Martin NJ, Sanghani S, Tilburt J, Pollak KI, Davis AD, Garde C, Barry MJ, El-Jawahri A, Quintiliani L, Sciacca K, Goldman J, Tulsky JA.   +22 more
europepmc   +1 more source

Benefits of targeted deployment of physician-led interprofessional pre-hospital teams on the care of critically ill and injured patients: the 'science' explained. [PDF]

Scand J Trauma Resusc Emerg Med
Christian MD, Lavery MD, Aulakh A.
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Pacemakers in Modern Cardiology and Their Transition From Traditional to Leadless Models. [PDF]

Cureus
Serbetci YA, Jaryal S, Bhasin I, Elhassan M, Muslim A, Aquilini P, Reddy A L, Tavera D, Caicco AP, Rai M.   +9 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

P02.197. Self help intervention to decrease stress and increase mindfulness: a pilot trial

BMC Complementary and Alternative Medicine, 2012
Sharma V, Bauer B, Prasad K, Sood A, Schroeder D   +4 more
doaj   +1 more source

Reinforcement Learning in Personalized Medicine: A Comprehensive Review of Treatment Optimization Strategies. [PDF]

Cureus
K B, Venkatesan L, Benjamin LS, K V, Satchi NS.   +4 more
europepmc   +1 more source

Cancer and Traditional Medicine: An Integrative Approach. [PDF]

Pharmaceuticals (Basel)
Sulaiman C, George BP, Balachandran I, Abrahamse H.   +3 more
europepmc   +1 more source