Results 91 to 100 of about 17,635 (289)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Ötekileştirilen Dindar Gençlik: ‘İmam Hatipler Kapatılsın’ Facebook Grubu Örneği

İlahiyat Akademi, 2020
Sosyal medya, bilgisayar ve iletişim teknolojilerindeki gelişmeler sonucu meydana gelmiştir. Bu alan içerisinde ortaya çıkmış sanal cemaatler insanların eğlendiği, boş vakit geçirdiği ve hobilerini paylaştığı gruplar olarak bilinmektedir.
Abdullah Özbolat, Mehmet Ertuğrul Evyapar   +1 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Othering Older People’s Housing: Gaming Ageing to Support Future-Planning [PDF]

The ‘othering’ of ageing is linked to an integrated process of ageism and hinders future planning for both individuals and practitioners delivering housing and health services.
Gibson, Joan, Pengelly, Ro, Joan Gibson, Katie Maginn, Ro Pengelly, Maginn, Katie, Davison, Lisa, Pemble, Catherine M, Melanie Lovatt, Scrutton, Pat, Alasdair C. Rutherford, Vikki McCall, Martin Quirke, Catherine M. Pemble, Jagannath, Sadhana, McCall, Vikki, Njoki, Mary, Quirke, Martin, Pat Scrutton, Lovatt, Melanie, Lisa Davison, Alison Bowes, Rutherford, Alasdair C, Mary Njoki, Sadhana Jagannath, Bowes, Alison   +25 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Fremdheitserfahrungen und Othering Ordnungen des »Eigenen« und »Fremden« in interreligiöser Bildung

Cover -- Inhalt -- Vorwort und Danksagung -- I. Vorbemerkungen -- 1. Anmerkungen zum Aufbau und Anliegen vorliegender Studie -- 2. Anmerkungen zum Begriff interreligiöser Bildung -- II.
Freuding, Janosch.
core