Results 101 to 110 of about 103,745 (353)
Physiological care for the mucosa of the nose: prevention of ARVI
Медицинский совет, 2019 The article highlights the role and place of elimination and irrigation therapy in the treatment and prevention of acute respiratory infections in children.
N. E. Payganova, Kh. Sh. Davudov
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LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma
Advanced Science, EarlyView.This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang +13 more
wiley +1 more source
Analysis of prevalence, aetio-pathology of tinnitus and role of caroverine as a primary treatment option among the patients attending a tertiary care hospital [PDF]
Al Ameen Journal of Medical SciencesBackground: Tinnitus, characterized by the perception of sound in the absence of an external stimulus, is increasingly prevalent in ENT practice across India.
Alfisha Sulthana +4 more
doaj
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
Label‐Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening
Advanced Science, EarlyView.A label‐free organoid photoacoustic imaging (LFOPI) system is developed for precise volumetric drug screening evaluation. As a proof of concept, LFOPI's performance in chemotherapy and immunotherapy drug screening assays are further evaluated. The LFOPI offers unique non‐invasive, label‐free capabilities for tumor organoids, and contributes to the ...
Xiaofei Luo +18 more
wiley +1 more source
Development of computer-aided surgery for otorhinolaryngology [PDF]
, 1998 Ludger Klimek +3 more
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Advanced Science, EarlyView.Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai +14 more
wiley +1 more source
Advanced Science, EarlyView.In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao +13 more
wiley +1 more source
Book Review: Atlas of Otorhinolaryngology and Bronchoesophagology [PDF]
, 1969 Michael O Carruthers
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