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Genetic basis of otosclerosis [PDF]

open access: yesSrpski Arhiv za Celokupno Lekarstvo, 2020
Introduction. Otosclerosis is a disorder of the bone labyrinth and stapes resulting in conductive hearing loss. The genetic basis of otosclerosis still remains unknown. We aimed at reporting a comprehensive review of up-to-date knowledge on genetic basis
Zukić Branka   +5 more
doaj   +1 more source

Does bilateral otosclerosis make pre-operative bone conduction more inaccurate?

open access: yesJournal of Otology, 2021
Objectives: To assess whether bilateral otosclerosis renders pre-operative bone conduction more inaccurate by increasing the Carhart effect. Methods: Retrospective review of a database of pre and post-operative audiograms of 745 ears with otosclerosis ...
Fiona McClenaghan, Jeremy Lavy
doaj   +1 more source

Role of MRI as first-line modality in the detection of previously undiagnosed otosclerosis: a single tertiary institute experience

open access: yesInsights into Imaging, 2020
Background Otosclerosis causes conductive, sensorineural and mixed hearing loss (CHL, SNHL, MHL) and tinnitus in young adults. It is best diagnosed on high-resolution CT (HRCT).
Bela Purohit   +2 more
doaj   +1 more source

Imaging Studies in Otosclerosis: An Up-to-date Comprehensive Review

open access: yesInternational Archives of Otorhinolaryngology, 2021
Introduction Otosclerosis is a primary osteodystrophy of the otic capsule, frequently responsible for acquired hearing loss in adults. Although the diagnostic value of imaging investigations in otosclerosis is debatable, they might still be employed with
Lucas Resende Lucinda Mangia   +4 more
doaj   +1 more source

Analysis of the Genetic Characteristics of a Chinese Family With Otosclerosis

open access: yesEar, Nose & Throat Journal, 2021
Background: Otosclerosis is a focal lesion of the inner ear. The role of genetic factors in the pathogenesis of otosclerosis has received increasing attention. We analyzed the clinical manifestations, inheritance pattern, and pathogenic genes in a family
Yongli Zhang BS   +5 more
doaj   +1 more source

Bisphosphonate therapy in otosclerosis: A scoping review

open access: yesLaryngoscope Investigative Otolaryngology, 2022
Objective Otosclerosis, a leading cause of deafness in adults, results from defective bone remodeling of the otic capsule. Bisphosphonates have been used to decrease bone remolding in many diseases, including otosclerosis.
René E. Zimmerer   +3 more
doaj   +1 more source

Cochlear Otosclerosis: An Undiagnosed Cause of Progressive Sensorineural Hearing Loss

open access: yesBengal Journal of Otolaryngology and Head Neck Surgery, 2020
Introduction Otosclerosis presents as conductive or mixed hearing loss depending upon the stage of the disease. Isolated sensorineural hearing loss though known to occur has been rarely reported.
Asish Kumar Lahiri   +4 more
doaj   +1 more source

Generation of an integration-free induced pluripotent stem cell line (JTUi004-A) from an otosclerosis patient

open access: yesStem Cell Research, 2022
Otosclerosis is caused by abnormal bone remodeling in the middle ear, resulting in progressive hearing loss, dizziness, balance problems, and tinnitus.
Hongmin Wu   +6 more
doaj   +1 more source

Investigation of Vestibular Aqueduct in High-Resolution CT Scan in Patients with Otosclerosis [PDF]

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2023
Background and Objective: Otosclerosis is caused by abnormal bone remodeling in the middle ear, which is associated with dizziness and lightheadedness.
M Pourasadegh   +5 more
doaj  

Establishment of an induced pluripotent stem cell line (JTUi003-A) from a patient with otosclerosis

open access: yesStem Cell Research, 2022
Otosclerosis is characterized by abnormal bone remodeling in the osseous labyrinth and progressive hearing loss. Although the etiology of otosclerosis is not fully understood, both environmental and genetic factors play important roles in its ...
Yuanping Xiong   +6 more
doaj   +1 more source

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