Results 171 to 180 of about 869,851 (265)

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Brain structure abnormalities in neurodevelopmental synaptopathies. [PDF]

Neuroimage Clin
Romagosa-Perez J, Ribeiro-Constante J, Julià-Palacios NA, Darling A, Marí-Vico R, Valls-Esteve A, Olivella M, Altafaj X, Synaptopathies-Working Group, Stephan-Otto C, García-Cazorla A.   +10 more
europepmc   +1 more source

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

Implementation and User Evaluation of an On-Premise Large Language Model in a German University Hospital Setting: Cross-Sectional Survey. [PDF]

JMIR AI
Grünig A, Kriebel J, Varghese J, Herrmann T, Sandmann S, Bruns C.   +5 more
europepmc   +1 more source

Environmental justice in education for climate action: Case studies from Perú and Uganda

Children &Society, EarlyView.
Abstract This paper draws on participatory research with secondary school learners in Perú and Uganda that shows how environmental and social (in) justices are interwoven and embedded in young people's experiences of the natural world. These experiences contrast with learners' accounts of environmental education in secondary schooling, in which the ...
Rachel Wilder, Expedito Nuwategeka, Carlos Monge, Alithu Bazan Talavera   +3 more
wiley   +1 more source

Gut microbe-generated metabolite trimethylamine N-oxide and risk of abdominal aortic aneurysm: a cohort study. [PDF]

Eur Heart J
Li XS, Wang M, Wang Z, Fan B, Tian MY, Filippazzo J, Lee Y, Mallela DP, Mao K, Liu Y, Lemaitre RN, Xie V, Diaz E, DiDonato JA, Tang WHW, de Oliveira Otto MC, Budoff MJ, Owens AP, Newman AB, Cameron SJ, Siscovick DS, Lusis AJ, Mozaffarian D, Hazen SL.   +23 more
europepmc   +1 more source

Trust in skincare and topical therapies in atopic dermatitis or psoriasis: a German cross‐sectional study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trust in therapy impacts adherence and satisfaction in chronic inflammatory skin diseases, including atopic dermatitis (AD) and psoriasis (PSO). This study assessed and compared trust in skincare and topical therapies and explored influencing factors among AD and PSO patients.
Svenja Royeck, Anna Daphne Bamidis, Conrad Weckbecker, Silke C. Hofmann, Sonja Ständer, Stefan W Schneider, Angelika Weigel, Natalija Novak, Dagmar Wilsmann‐Theis, Galina Balakirski   +9 more
wiley   +1 more source

Mapping Metastatic Spread in Uterine Sarcoma: A Population-Based Analysis of First Metastatic Patterns and Outcomes. [PDF]

Cancers (Basel)
Gennari P, Ignatov A.
europepmc   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients. [PDF]

Br J Clin Pharmacol
Rasmussen ASB, Koch MR, Rank CU, Andersen CL, Weimann A, Thastrup M, Yang T, Lund TM, Christensen IJ, Nielsen F, Stage TB, Jensen SB, Andersen MK, Schmiegelow K, Dalhoff K.   +14 more
europepmc   +1 more source

Oviposition Site Selection in Relation to Hatchling Feeding Performance in Two Sympatric Papilio Butterflies

Entomologia Experimentalis et Applicata, EarlyView.
We investigated oviposition site selection and hatchling feeding performance in two sympatric swallowtail butterflies, Papilio xuthus and Papilio memnon (Lepidoptera: Papilionidae), that utilize Citrus trees as host plants. Our study suggests that each species has unique relationships between maternal oviposition preferences and hatchling feeding ...
Gakuto Nihei, Suzuki Noriyuki
wiley   +1 more source