Results 91 to 100 of about 168,020 (265)

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

Mechanical chest-compression devices: current and future roles [PDF]

, 2010
Purpose of review: It is recognised that the quality of CPR is an important predictor of outcome from cardiac arrest yet studies consistently demonstrate that the quality of CPR performed in real life is frequently sub-optimal.
Brace, Samantha J., Gates, Simon, Perkins, Gavin D.   +2 more
core   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Successful cardiac arrest resuscitation by a layperson participant in a novel AED-equipped response corps: A case report

Resuscitation Plus
Survival from out-of-hospital cardiac arrest (OHCA) is highly dependent on the time to initial resuscitation efforts. When OHCA occurs in public environments, the probability of CPR-trained responders and proximal AED availability is higher than in ...
Benjamin S. Abella, Michael C. Kurz, Joshua M. Knapp, Stephanie M. Madonis, Julie Buckingham, Alan Wirt, Aarthi Kaviyarasu, Taylor Brothers, Matthew T. Kratz, Megan Ruby   +9 more
doaj   +1 more source

Epidemiology and outcomes from out-of-hospital cardiac arrests in England [PDF]

, 2017
Introduction This study reports the epidemiology and outcomes from out-of-hospital cardiac arrest (OHCA) in England during 2014. Methods Prospective observational study from the national OHCA registry.
Booth, Scott J., Brace-McDonnell, Samantha J., Brown, Terry, Cooke, Matthew, Deakin, Charles D., Fothergill, Rachael, Gale, Chris P., HASH(0x5570cb428980), Hawkes, C. M., Ji, Chen, Mapstone, James, Nolan, Jerry P., Perkins, Gavin D., Rees, Nigel, Siriwardena, A. Niroshan, Soar, Jasmeet, Whittington, Andrew   +16 more
core   +1 more source

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

Advanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl, Finn Jaekel, Julia Henne, Richard Kantelberg, Daniel C. Freund, Eberhard Grambow, Brigitte Vollmar, Amelie R. Zitzmann, Hans Kleemann, Jochen Hampe, Sebastian Hinz, Clemens Schafmayer, Karl Leo   +12 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The association of extreme environmental heat with incidence and outcomes of out-of-hospital cardiac arrest in British Columbia: A time series analysis

Resuscitation Plus
Background: The impact of extreme heat on out-of-hospital cardiac arrest (OHCA) incidence and outcomes is under-studied. We investigated OHCA incidence and outcomes over increasing temperatures.
Laiba Khan, Takahisa Kawano, Jacob Hutton, Michael Asamoah-Boaheng, Frank X. Scheuermeyer, Michael Christian, Leon Baranowski, David Barbic, Jim Christenson, Brian Grunau   +9 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Underlying Cause of Out‐of‐Hospital Cardiac Arrests in Japan in Survivors Versus Nonsurvivors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The causes underlying out‐of‐hospital cardiac arrest (OHCA) are rarely investigated. This study aimed to investigate causes of OHCA in CRITICAL (Comprehensive Registry of In‐Hospital Intensive Care for OHCA Survival), a multicenter OHCA ...
Satoshi Yoshimura, Zian H. Tseng, Tomoki Yamada, Shunichiro Nakao, Kazuhisa Yoshiya, Changhwi Park, Tetsuro Nishimura, Takuya Ishibe, Kazuma Yamakawa, Takeyuki Kiguchi, Masafumi Kishimoto, Kohei Ninomiya, Yusuke Ito, Taku Sogabe, Takaya Morooka, Haruko Sakamoto, Yuki Hironaka, Atsunori Onoe, Tasuku Matsuyama, Yohei Okada, Satoshi Matsui, Norihiro Nishioka, Shunsuke Kimata, Shunsuke Kawai, Yuto Makino, Ling Zha, Kosuke Kiyohara, Tetsuhisa Kitamura, Taku Iwami   +28 more
doaj   +1 more source