Results 61 to 70 of about 168,020 (265)

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Risk factors and outcome of extracorporeal cardiopulmonary resuscitation patients with out-of-hospital cardiac arrest and in-hospital cardiac arrest: a nationwide prospective and observational study of 939 hospitals in China

BMC Emergency Medicine
Background Sudden cardiac arrest represents a global health challenge characterized by high mortality and morbidity rates. Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly considered as an effective treatment for cardiac arrest ...
Di Shi, Bo Li, Wei Pan, Fuping Guo, Hui Jiang, Liu Chengxi, Huadong Zhu, Jihai Liu, Jieqing Chen, Liang Zong, Xiao Song, Chen Lin, Xin Ding, Xiang Zhou, Chang Yin, Bin Du, on behalf of the China National Critical Care Quality Control Center-the ECMO quality improvement action (EQIA) study   +16 more
doaj   +1 more source

Out-of-hospital cardiopulmonary resuscitation in four Serbian university cities: outcome follow-up according to the «Utstein style» [PDF]

, 2010
Aims. To investigate the return of spontaneous circulation (ROSC), survival to discharge, six-month and one-year survival of patients with out-of-hospital cardiac arrest in four university cities in Serbia. Methods.
NATASA DJORDJEVIC, SLADJANA ANDJELIC
core   +1 more source

National initiatives to improve outcomes from out-of-hospital cardiac arrest in England [PDF]

, 2015
NHS England report that the ambulance services attempt to resuscitate approximately 28 000 people from out-of-hospital cardiac arrest each year (approximately 1 per 2000 inhabitants per year).1 The rate of initial success (return of spontaneous ...
de Belder, Mark, Gray, Huon, Lockey, Andrew S., Moore, Fionna, Perkins, Gavin D., Weissberg, Peter   +5 more
core   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

First automated detection of a cardiac arrest using a commercially available smartwatch: a case report

Resuscitation Plus
Background: Automated cardiac arrest detection aims to shorten the time between arrest onset and emergency medical services activation, thereby reducing the number of unwitnessed out-of-hospital cardiac arrests (OHCA) and shortening time to treatment in ...
Wisse M.F. van den Beuken, Pieter R. Tuinman, Beat Nideröst, Sebastiaan A. Goossen, Hans van Schuppen, Stephan A. Loer, Lothar A. Schwarte, Patrick Schober   +7 more
doaj   +1 more source

Cardiac arrest after STEMI and importance of early cardiopulmonary resuscitation in non hospital setting-time is life/myocard [PDF]

ABC: časopis urgentne medicine, 2016
INTRODUCTION: In 23 % of cases, sudden cardiac death can be the first manifestation of coronary artery disease. In these cases pulseless VT and VF are the most common causes for cardiac arrest.
Niković Vuk, Kojić Dejan, Milenković Dušan, Bulajić Ranka, Hodžić Edvin, Boljević Aleksandra   +5 more
doaj  

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Methodology for creating a novel cardiac arrest registry using the Trinetx electronic health record database

Resuscitation Plus
Background: Care in the hospital, post-arrest care, is a crucial component of out-of-hospital cardiac arrest (OHCA) management, but current OHCA databases contain limited post-arrest care data. To address this, we present the methodology for assembling a
Ryan Huebinger, Ryan A. Coute, Larissa Myaskovsky, Cameron Crandall, Ethan Abbott, Keith E. Kocher, Aditya C Shekhar, Benjamin S. Abella   +7 more
doaj   +1 more source