Results 111 to 120 of about 179,681 (354)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The association of extreme environmental heat with incidence and outcomes of out-of-hospital cardiac arrest in British Columbia: A time series analysis

Resuscitation Plus
Background: The impact of extreme heat on out-of-hospital cardiac arrest (OHCA) incidence and outcomes is under-studied. We investigated OHCA incidence and outcomes over increasing temperatures.
Laiba Khan, Takahisa Kawano, Jacob Hutton, Michael Asamoah-Boaheng, Frank X. Scheuermeyer, Michael Christian, Leon Baranowski, David Barbic, Jim Christenson, Brian Grunau   +9 more
doaj   +1 more source

211 Comparison of Emergency Department and Out-of-Hospital Cardiac Arrest Patients Monitored With End Tidal CO2 and Cerebral Oximetry [PDF]

, 2012
J. Wilburn, James C. Cloyd, Brian J. O’Neil, P. Medado, Timothy E. Scott, Thomas Engel   +5 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Underlying Cause of Out‐of‐Hospital Cardiac Arrests in Japan in Survivors Versus Nonsurvivors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The causes underlying out‐of‐hospital cardiac arrest (OHCA) are rarely investigated. This study aimed to investigate causes of OHCA in CRITICAL (Comprehensive Registry of In‐Hospital Intensive Care for OHCA Survival), a multicenter OHCA ...
Satoshi Yoshimura, Zian H. Tseng, Tomoki Yamada, Shunichiro Nakao, Kazuhisa Yoshiya, Changhwi Park, Tetsuro Nishimura, Takuya Ishibe, Kazuma Yamakawa, Takeyuki Kiguchi, Masafumi Kishimoto, Kohei Ninomiya, Yusuke Ito, Taku Sogabe, Takaya Morooka, Haruko Sakamoto, Yuki Hironaka, Atsunori Onoe, Tasuku Matsuyama, Yohei Okada, Satoshi Matsui, Norihiro Nishioka, Shunsuke Kimata, Shunsuke Kawai, Yuto Makino, Ling Zha, Kosuke Kiyohara, Tetsuhisa Kitamura, Taku Iwami   +28 more
doaj   +1 more source

Mechanical chest-compression devices: current and future roles [PDF]

, 2010
Purpose of review: It is recognised that the quality of CPR is an important predictor of outcome from cardiac arrest yet studies consistently demonstrate that the quality of CPR performed in real life is frequently sub-optimal.
Brace, Samantha J., Gates, Simon, Perkins, Gavin D.   +2 more
core   +1 more source

Outcome Predictors of Patients in Out-Of-Hospital Cardiac Arrests with Pre-Hospital Defibrillation in Hong Kong [PDF]

, 2013
TH Chan, CT Lui, KH Cheung, YH Tang, Kwok‐Leung Tsui   +4 more
openalex   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Epidemiology and outcomes of out-of-hospital cardiac arrests at sport and recreational events in England, 2015–2022

Resuscitation Plus
Background: Previous studies suggest favourable outcomes for patients experiencing exercise-related out-of-hospital cardiac arrest (OHCA). This study aimed to examine the characteristics and outcomes of OHCAs occurring at sports and recreational events ...
Helen Winterburn, Gavin D. Perkins, Chen Ji, Scott Booth, Adam de Paeztron, Rachael Fothergill, Terry P. Brown   +6 more
doaj   +1 more source

Out of hospital cardiac arrest: when to resuscitate

The Pan African Medical Journal, 2019
INTRODUCTION: This study explores why resuscitation is withheld when mobile emergency medical team arrive at the scene of a cardiac arrest.
Saida Zelfani, Hela Manai, Yosra Riahi, Mounir Daghfous   +3 more
doaj   +1 more source