Results 21 to 30 of about 345,042 (281)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Magnitude of Out of Pocket Health Expenditures and Associated Factors Among Civil Servants [PDF]

, 2015
In Ethiopia, as other developing countries, public health care is provided at nominally low prices and free to those that does not afford to pay. But the health care consumer population is still to make considerable amount of out-of-pocket health ...
Gedefaw, M. (Molla), Geremew, M. (Mekuanenet), Kassa, G. M. (Getachew), Tsegay, G. (Girmay)   +3 more
core  

Catastrophic health expenditure and associated factors among adult diabetes patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

BMC Health Services Research
Introduction Out-of-pocket health expenditures pose a substantial financial burden for millions of people worldwide. Diabetes patients without financial protection often face catastrophic out-of-pocket health expenditure. However, the catastrophic out-of-
Kibret Mesgie, Asmamaw Atnafu, Tesfahun Zemene Tafere, Nigusu Worku, Banchlay Addis, Asebe Hagos   +5 more
doaj   +1 more source

Hypertension in urban slums of southern India: Burden, awareness, health seeking, control and risk factor profile

Indian Heart Journal, 2023
Introduction: Hypertension is the leading risk factor for global disease burden. Inequalities in health among urban poor and non-poor is a matter of concern. The current study was done to estimate the prevalence of hypertension and to describe the health
P.S. Rakesh, B.A. Renjini, Sreelakshmi Mohandas, Jaideep Menon, Mathews Numpelil, Aswathy Sreedevi, Beena Vasudevan   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Equity in out-of-pocket payment in Chile [PDF]

Revista de Saúde Pública, 2017
To assess the distribution of financial burden in Chile, with a focus on the burden and progressivity of out-of-pocket payment.Based on the principle of ability to pay, we explore factors that contribute to inequities in the health system finance and issues about the burden of out-of-pocket payment, as well as the progressivity and redistributive ...
Mondaca, Alicia Lorena Núñez, Chi, Chunhuei   +1 more
openaire   +5 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Revisiting 'Skin in the Game' Among Medicare Beneficiaries: An Updated Analysis of the Increasing Financial Burden of Health Care Spending From 1997 to 2005 [PDF]

, 2009
Presents data on the out-of-pocket expenses of Medicare beneficiaries as a share of income, analyzed by insurance status, region, and various demographics, as well as spending percentile.
Anthony Damico, Juliette Cubanski, Tricia Neuman   +2 more
core  

Catastrophic Health Expenditure among Chronic Patients Attending Dessie Referral Hospital, Northeast Ethiopia

ClinicoEconomics and Outcomes Research, 2021
Yohannes Shumet,1 Solomon Ahmed Mohammed,2 Mesfin Haile Kahissay,2 Birhanu Demeke2 1Department of Pharmacy, College of Medicine and Health Science, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Pharmacy, College of Medicine and Health ...
Shumet Y, Mohammed SA, Kahissay MH, Demeke B   +3 more
doaj  

Exploring dynamics in catastrophic health care expenditure in Nigeria

Health Economics Review, 2022
Background The Nigeria’s National Health Insurance Scheme aimed at making health care accessible and affordable since it’s became operational in 2005. However, many Nigerians still pay out of pocket for medical expenses, and this drive them to incurring ...
Henry C. Edeh
doaj   +1 more source