Results 121 to 130 of about 167,712,618 (323)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Understanding the trends of public spending on health sector: World Health Organization

Indian Journal of Community and Family Medicine, 2020
Since the global leaders have adopted the Sustainable Development Goals, major steps have been taken by different nations to attain the goal of universal health coverage.
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava   +1 more
doaj   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

The Risk of Out-of-Pocket Health Care Expenditure at End of Life [PDF]

There is conflicting evidence on the importance of out-of-pocket medical expenditures as a risk to financial security, particularly at older ages. We revisit this question, focusing on health care spending near the end of life using data from the Health ...
Samuel Marshall, Jonathan S. Skinner, Kathleen M. McGarry   +2 more
core  

Pathways to Reduce Household Out-of-Pocket Expenditure

, 2020
Bangladesh allocates a much smaller share of the government budget to health than countries of similar income level. Reallocation is politically challenging but could offer the biggest potential source of fiscal space for health, larger than the space that economic growth can bring.
Bonilla-Chacin, Maria Eugenia, Hossain, Md. Rafi, Mahmud, Md. Shahadt Hossain, Amin, Md. Nural, Sarker, Mohammad Abul Bashar, Sadat, Muhammad Anwar, Paul, Subrata, Ahmed, Shakil, Begum, Tahmina, Smith, Owen, Kumar, Anurag   +10 more
openaire   +2 more sources

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Financing Healthcare in Nigeria: Impact of Out-of-Pocket Expenditure [PDF]

, 2019
This research work scrutinized the impact of out-of-pocket expenditure on healthcare financing in Nigeria. It was observed that out of pocket expenditure of Nigeria within the period under review has been marginally increasing.
Egiyi, Modesta Amaka
core   +1 more source

Estimation of Out of Pocket Expenditure Under Janani Shishu Suraksha Karayakram (JSSK) in Rural Block of Chhattisgarh: A Community Based Cross-Sectional Study

National Journal of Community Medicine, 2017
Background: In order to reduce out-of-pocket expenditure during institutional delivery, Govt. of India has launched a nationwide initiative - Janani Shishu Suraksha Karyakram (JSSK) which provides cashless services to pregnant mothers & sick infants ...
Aditi Chandrakar, Gopal Soni, Ashish Sinha, Kamlesh Jain, Prem Panda, Somen Pradhan   +5 more
doaj  

Nonlinear Quantum Effects Drive Grotthuss Proton Conduction in Structured Electrolytes Based on Deep Eutectic Solvents

Advanced Science, EarlyView.
We demonstrate that the inverse relationship between viscosity and conductivity in structured electrolytes can be circumvented by leveraging their hydrogen bonding networks for Grotthuss proton transport. Using a mixture of imidazole and levulinic acid, we show that the existence of extended hydrogen‐bonded chains that can rapidly reorient result in ...
Benworth B. Hansen, Michael S. Chen, Giselle de A. L. e Souza, Kaylie Glynn, Alan Robledo, Emilia Pelegano‐Titmuss, Katherine Hightower, Miguel Muñoz, Rathiesh Pandian, Clemens Burda, Aikaterini Sanida, Mark Dadmun, Burcu E. Gurkan, Steve G. Greenbaum, Mark E. Tuckerman, Joshua R. Sangoro   +15 more
wiley   +1 more source

Out of Pocket Expenditure for Sick Newborn Care in Referral Hospitals of Nepal

Maternal and Child Health Journal, 2020
Background Almost all preventable neonatal deaths take place in low- and middle-income countries and affect the poorest who have the least access to high quality health services.
Avinash K. Sunny, Rejina Gurung, Abhishek Gurung, Omkar Basnet, Ashish Kc   +4 more
semanticscholar   +1 more source