Results 121 to 130 of about 10,065,466 (362)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Strengthening Out-of-School Time Nonprofits: The Role of Foundations in Building Organizational Capacity [PDF]
, 2008 Placing nonprofits in the larger context of city, state, and national policy, explores the capacity-building support nonprofits running afterschool and summer programs need to provide high-impact networks of learning and developmental ...
Heather B. Weiss, Priscilla Little
core
Conceptualization of Out-of-School Mathematics Education
Yaşadıkça EğitimOut-of-school mathematics education is a relatively new domain. This paper examines learning environments in out-of-school mathematics education, where teachers play a role.
Mehtap Kuş
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The Cost of Quality Out-of-School-Time Programs [PDF]
, 2009 Funders and program planners want to know: What does it cost to operate a high-quality after-school or summer program? This study answers that question, discovering that there is no "right" number.
Andrew Gersick +4 more
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
A New Day for Youth: Creating Sustainable Quality in Out-of-School Time [PDF]
, 2008 Reviews research on best practices and examines the elements needed to create and sustain high-quality afterschool and summer programs. Recommends a framework for improving staff capacity and training, support structures and leadership, and ...
Gil G. Noam
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Charging for school activities [PDF]
, 2009 "The purpose of this guidance is to help head teachers and governing bodies set out their policies on charging and remission for school activities and school visits.
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source