Results 71 to 80 of about 1,185,498 (335)

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Cross-border outbreak of Yersinia enterocolitica bioserotype 2/O:9 infections associated with consumption of French unpasteurised soft goat’s milk cheese, 2024

Eurosurveillance
In March 2024, the French genomic surveillance of enteric yersiniosis identified a cluster of lineage 2/3–9b Yersinia enterocolitica isolates, corresponding to bioserotype 2/O:9.
Y. enterocolitica Outbreak Investigation Group
doaj   +1 more source

Working Paper: Are Voters Polarized Along Party Lines About How to Run Elections During the COVID-19 Crisis? [PDF]

, 2021
Are voters as polarized as political leaders when it comes to their preferences about how to cast their ballots in November 2020 and their policy positions on how elections should be run in light of the COVID-19 outbreak? Prior research has shown little
HILL, Seth, Kousser, Thaddeus, Lockhart, Mackenzie, Merolla, Jennifer, Romero, Mindy   +4 more
core  

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Assessment of a health facility based active case finding system for Ebola virus disease in Mbandaka, Democratic Republic of the Congo, June–July 2018

BMC Infectious Diseases, 2019
Background The ninth outbreak of Ebola Virus Disease (EVD) in the Democratic Republic of the Congo occurred in Équateur Province from 8 May-24 July 2018.
Amber Kunkel, Mory Keita, Boubacar Diallo, Olivier le Polain de Waroux, Lorenzo Subissi, Bocar Wague, Roger Molala, Pierre Lonfandjo, Sébastien Bokoo Bokete, William Perea, Mamoudou Harouna Djingarey   +10 more
doaj   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Local outbreaks of Operophtera brumata and Operophtera fagata cannot be explained by low vulnerability to pupal predation [PDF]

, 2013
One of the unresolved questions in studies on population dynamics of forest Lepidoptera is why some populations at times reach outbreak densities, whereas others never do.
Heisswolf, Annette, Klemola, Tero, Käär, Miia, Ruohomäki, Kai   +3 more
core  

Stratified dispersal and increasing genetic variation during the invasion of Central Europe by the western corn rootworm, Diabrotica virgifera virgifera [PDF]

, 2010
Invasive species provide opportunities for investigating evolutionary aspects of colonization processes, including initial foundations of populations and geographic expansion.
Anonymous, Baufeld, Benjamini, Bialozyt, Boriani, Ciosi, Ciosi, Coats, Coombs, Corander, Corander, Cornuet, Davies, Drake, Edmonds, Edwards, Elam, Estoup, Evanno, Excoffier, Falush, Fisher, Gaggiotti, Genton, Grant, Gray, Guillot, Guillot, Hallatschek, Hallatschek, Hubisz, Ibrahim, Isard, Johnson, Kim, Kim, Kirkpatrick, Kiss, Klopfstein, Le Corre, Metcalf, Miller, Miller, Moody, Nei, Olden, Onstad, Paetkau, Pascual, Petit, Pimentel, Piry, Pritchard, Pritchard, Pritchard, Prugnolle, R Development CoreTeam, Rannala, Raymond, Raymond, Ripka, Roman, Rosenberg, Rousset, Ruiz, Sax, Shigesada, Sivcev, Sivcev, Slatkin, Sokal, Spencer, Sunnucks, Voisin, Weir, Williams   +75 more
core   +4 more sources

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Prevalence of Salmonella on commercial layer farms in Barbados, 2009-2010 [PDF]

, 2012
During January-March 2009, an outbreak of Salmonella was detected in four commercial layer farms in Barbados. During the outbreak, a total of 511 layers died, and 3,257 layers were voluntarily culled from one affected farm.
Aimey, Vicki, Delgado, Amy, Hernandez, Jorge, Hunte, Kerrilyn, Lefrançois, Thierry, Sanford, Bryan, Shaw, J., St John, V., Trotman, Mark, Whitehall, Pamela   +9 more
core