Results 51 to 60 of about 402,089 (247)

Enhanced One‐Pot Dual‐CRISPR‐Based Assay Lyophilized on a 3D‐Printed Disc for Field‐Deployable Multiplex Bacteria Detection

Advanced Science, EarlyView.
An enhanced one‐pot, helicase‐assisted recombinase polymerase amplification (hRPA)‐combined, dual‐CRISPR/uAsCas12a assay is developed and lyophilized on a 3D‐printed microfluidic disc to achieve field‐deployable multiplex bacteria detection. Abstract One‐pot CRISPR‐based detection combining recombinase polymerase amplification (RPA) enables rapid and ...
Yuqing Shen, Bo Lu, Biao Ma, Xiong Ding
wiley   +1 more source

Clinical signs, diagnosis, and case reports of Vaccinia virus infections

Brazilian Journal of Infectious Diseases
Vaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold.
Daniela Carla Medeiros Silva, Eduardo Augusto dos Santos Moreira-Silva, Juliana de Assis Silva Gomes, Flávio Guimarães da Fonseca, Rodrigo Correa-Oliveira   +4 more
doaj   +1 more source

Hospital Outbreaks of Middle East Respiratory Syndrome, Daejeon, South Korea, 2015

Emerging Infectious Diseases, 2017
From May through July 2015, a total of 26 cases of Middle East Respiratory Syndrome were reported from 2 hospitals in Daejeon, South Korea, including 1 index case and 25 new cases.
Jung Wan Park, Keon Joo Lee, Kang Hyoung Lee, Sang Hyup Lee, Jung Rae Cho, Jin Won Mo, Soo Young Choi, Geun Yong Kwon, Ji-Yeon Shin, Jee Young Hong, Jin Kim, Mi-Yeon Yeon, Jong Seok Oh, Hae-Sung Nam   +13 more
doaj   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Hepatitis E Outbreak on Cruise Ship

Emerging Infectious Diseases, 2009
In 2008, acute hepatitis E infection was confirmed in 4 passengers returning to the United Kingdom after a world cruise. Epidemiologic investigation showed that of 789 persons who provided blood samples, 195 (25%) were seropositive, 33 (4%) had ...
Bengü Said, Samreen Ijaz, George Kafatos, Linda Booth, H. Lucy Thomas, Amanda Walsh, Mary Ramsay, Dilys Morgan   +7 more
doaj   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, EarlyView.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

Advanced Science, EarlyView.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang, Jie‐Mei Zhao, Chuan‐Yu Xiang, Yi‐Wen Ma, Hong‐Peng Lei, Yu‐Ying Shi, Shun Zhou, Xiaofei Zeng, Jinsong Chen, Fei Liu, Benhe Zeng, Rui Song, Ye Hu, Feng Zhang, Xiang Liu, Wen‐Xiang Li, Gui‐Tang Wang, Ivan Jakovlić   +17 more
wiley   +1 more source

Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches

Memorias do Instituto Oswaldo Cruz, 2015
Orally transmitted Chagas disease has become a matter of concern due to outbreaks reported in four Latin American countries. Although several mechanisms for orally transmitted Chagas disease transmission have been proposed, food and beverages ...
Belkisyolé Alarcón de Noya, Zoraida Díaz-Bello, Cecilia Colmenares, Raiza Ruiz-Guevara, Luciano Mauriello, Arturo Muñoz-Calderón, Oscar Noya   +6 more
doaj   +1 more source

Delayformer: Spatiotemporal Transformation for Predicting High‐Dimensional Dynamics

Advanced Science, EarlyView.
Delayformer introduces a multivariate spatiotemporal transformation (mvSTI) that converts observed variables into delay‐embedded states and cross‐learns their dynamics using a shared Vision Transformer encoder. This approach, grounded in dynamical systems theory, simultaneously predicts all variables in high‐dimensional systems, outperforming state‐of ...
Zijian Wang, Peng Tao, Luonan Chen
wiley   +1 more source