Results 111 to 120 of about 8,937,082 (369)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Treatment Effects on Ordinal Outcomes: Causal Estimands and Sharp Bounds [PDF]

open access: yesarXiv, 2015
Assessing the causal effects of interventions on ordinal outcomes is an important objective of many educational and behavioral studies. Under the potential outcomes framework, we can define causal effects as comparisons between the potential outcomes under treatment and control.
arxiv  

Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis

open access: yesDiabetes Care, 2016
Type 2 diabetes mellitus causes excessive morbidity and premature cardiovascular (CV) mortality. Although tight glycemic control improves microvascular complications, its effects on macrovascular complications are unclear.
S. Mudaliar, Sindura K. Alloju, R. Henry
semanticscholar   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

EGFR Testing Patterns and Detection of EGFR Exon 20 Insertions in the United States

open access: yesJTO Clinical and Research Reports, 2022
Introduction: EGFR exon 20 insertions (EGFRex20ins) are a diverse set of mutations in NSCLC that are refractory to tyrosine kinase inhibitors. We describe real-world EGFRex20ins detection patterns in patients with advanced NSCLC in the United States ...
Huamao M. Lin, PhD   +4 more
doaj  

The Italian version of rheumatoid arthritis pain scale (IT-RAPS): psychometric properties on community and clinical samples

open access: yesReumatismo, 2019
This paper describes the validation process of the Italian version of the Rheumatoid Arthritis Pain Scale (ITRAPS), describing its translation and adaptation to Italian culture.
M. Tofani   +7 more
doaj   +1 more source

Characterizing direct and indirect causal effects when outcomes are dependent due to treatment spillover and outcome spillover [PDF]

open access: yesarXiv
We provide novel insight into causal inference when both treatment spillover and outcome spillover occur in connected populations, by taking advantage of recent advances in statistical network analysis. Scenarios with treatment spillover and outcome spillover are challenging, because both forms of spillover affect outcomes and therefore treatment ...
arxiv  

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