Results 201 to 210 of about 10,060,126 (337)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Comparison of the predictive performance of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio for three-month poor functional outcome in ischemic stroke: a systematic review and meta-analysis. [PDF]

Ann Med
Ma X, Zhou Y, Li Z, Mao G, Wei H, Zhao T.   +5 more
europepmc   +1 more source

GrantWatch: Outcomes [PDF]

Health Affairs, 2009
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A data re-analysis confirms the value of symptom networks in predicting psychotherapy outcome. [PDF]

World Psychiatry
Schumacher L, Kriston L, Ebrahimi OV, Finnemann A, Klein JP, Haslbeck JMB.   +5 more
europepmc   +1 more source

Additional file 1: of Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone

, 2016
Yingjie Ji, Xuezhang Duan, Xudong Gao, Lei Li, Chen Li, Dong Ji, Wengang Li, Lifu Wang, Yuhua Meng, Xiao Yang, Bin-Fang Ling, Xueai Song, Mei-Lei Gu, Tao Jiang, Sheku M. Koroma, James Bangalie, Huijuan Duan   +16 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Protocol for the development of a global core outcome set for the surgical treatment of sacrococcygeal teratoma in children: a systematic review and international Delphi study. [PDF]

BMJ Open
Dongen MC, van Rijn R, Sharma S, Raphael MF, de Vries R, Abouzeid AA, Bugiani M, Chirdan LB, van Heurn ELW, Derikx JPM, Kremer MEB, Steering Group SC.   +11 more
europepmc   +1 more source

Official statistics release : early years and childcare inspections and outcomes : 1 September 2008 to 31 March 2012 : provisional [PDF]

, 2012
Sue Gregory, Steve Ball
openalex